Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, 266003, Qingdao, PR China.
Zhejiang Mariculture Research Institute, 325005, Wenzhou, PR China.
Mar Environ Res. 2023 Jan;183:105845. doi: 10.1016/j.marenvres.2022.105845. Epub 2022 Dec 9.
Currently, research on toxic effects of PCP Na is greatly insufficient. The aim of this study is to explore the toxic effects of PCP-Na for better conducting future work on PCP-Na toxicology. For this purpose, S. constricta adults were exposed to PCP-Na for toxicity testing. The results showed that PCP-Na could easily bioaccumulate in S. constricta and significantly affected both phrase I and II metabolism enzymes. Meanwhile, PCP-Na strongly activated antioxidant system and caused PC, LPO and DNA damage. In addition, neurotoxicity and immunotoxicity of PCP-Na was demonstrated in this study. Interestingly, we observed that PCP-Na significantly affected the expression of genes of electron transport chain and induced key enzymes of glycolysis, indicating that PCP-Na may act as an uncoupler of oxidative phosphorylation, interfering with energy supply and causing energy compensation. This study is the first to fully analyze and provide a new perspective on the toxicity of PCP-Na.
目前，有关 PCP-Na 的毒性作用的研究还很不足。本研究旨在探讨 PCP-Na 的毒性作用，以便更好地开展未来的 PCP-Na 毒理学研究。为此，我们选择了赤子爱胜蚓作为实验动物，进行了 PCP-Na 的毒性实验。结果表明，PCP-Na 容易在赤子爱胜蚓体内积累，并显著影响了 Phase I 和 Phase II 代谢酶。同时，PCP-Na 强烈激活了抗氧化系统，导致 PC、LPO 和 DNA 损伤。此外，本研究还证明了 PCP-Na 具有神经毒性和免疫毒性。有趣的是，我们观察到 PCP-Na 显著影响了电子传递链基因的表达，并诱导了糖酵解的关键酶，这表明 PCP-Na 可能作为氧化磷酸化的解偶联剂，干扰能量供应并导致能量补偿。本研究首次全面分析并提供了 PCP-Na 毒性的新视角。
