Zhang Ting, Wang Jiayu, Zhao Anjing, Xia Lu, Jin Haiyan, Xia Suhua, Shi Tongguo
Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, 178 East Ganjiang Road, Suzhou, China; Department of Oncology, The First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, China.
Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, 178 East Ganjiang Road, Suzhou, China.
Cytokine. 2023 Feb;162:156108. doi: 10.1016/j.cyto.2022.156108. Epub 2022 Dec 15.
Immunotherapy has been a promising, emerging treatment for various cancers. Gamma delta (γδ) T cells own a T cell receptor composed of γ- and δ- chain and act as crucial players in the anti-tumor immune effect. Currently, Vγ9Vδ2 T cells, the predominate γδ T cell subset in human peripheral blood, has been shown to exert multiple biological functions. In addition, a growing body of evidence notes that Vγ9Vδ2 T cells interact with tumor cells in many ways, such as TCR-mediated nonpeptidic-phosphorylated phosphoantigens (pAgs) recognization, NKG2D/NKG2D ligand (NKG2DL) pathway, Fas-FasL axis and antibody-dependent cellular cytotoxicity (ADCC) as well as exosome. More importantly, clinical studies with Vγ9Vδ2 T cells in cancers have propelled several clinical applications to investigate their safety and efficacy. Herein, this review summarized the underlying ways and mechanisms of interplay cancer cells and Vγ9Vδ2 T cells, which may help us to generate new strategies for tumor immunotherapy in the future.
免疫疗法一直是一种有前景的、新兴的针对各种癌症的治疗方法。γδ T细胞拥有由γ链和δ链组成的T细胞受体，在抗肿瘤免疫效应中起着关键作用。目前，Vγ9Vδ2 T细胞是人类外周血中占主导地位的γδ T细胞亚群，已被证明具有多种生物学功能。此外，越来越多的证据表明，Vγ9Vδ2 T细胞与肿瘤细胞以多种方式相互作用，如TCR介导的非肽磷酸化磷酸抗原（pAgs）识别、NKG2D/NKG2D配体（NKG2DL）途径、Fas-FasL轴和抗体依赖性细胞毒性（ADCC）以及外泌体。更重要的是，针对癌症患者的Vγ9Vδ2 T细胞临床研究推动了多项临床应用，以研究其安全性和有效性。在此，本综述总结了癌细胞与Vγ9Vδ2 T细胞相互作用的潜在方式和机制，这可能有助于我们在未来制定新的肿瘤免疫治疗策略。
