Ansarinasab Sheida, Ghassemi Farnaz, Tabanfar Zahra, Jafari Sajad
Department of Biomedical Engineering, Amirkabir University of Technology (Tehran polytechnic), Iran.
Department of Biomedical Engineering, Amirkabir University of Technology (Tehran polytechnic), Iran.
J Theor Biol. 2023 Mar 7;560:111381. doi: 10.1016/j.jtbi.2022.111381. Epub 2022 Dec 14.
Measuring the phase synchronization between different brain regions in functional brain networks is a common approach to investigate many psychological disorders such as Attention Deficit Hyperactivity Disorder (ADHD). The emotional processing deficit in ADHD children is one of the main obstacles in their social interactions. In this study, the nonlinear Correlation between Probability of Recurrences (CPR) method is used for the first time to construct functional brain networks of 22 boys with ADHD and 22 healthy ones during watching four visual-emotional stimuli types. Topological features of brain networks, including shortest path length, clustering coefficient, and nodes strengths, are investigated in groups of ADHD and healthy. The results indicate a significantly (P-Values < 0.01) greater average clustering coefficient and lower shortest path length in the brain networks of ADHD individuals than the healthy ones. Accordingly, in the ADHD brain networks, the information exchange in both local and global scales is abnormally more than the healthy ones, leading to a hyper-synchronization in this group. The topological alterations of ADHD brain networks are mainly observed in the brain's frontal and occipital lobes, indicating impaired brain function of this group in emotional and visual processing. This survey demonstrates that the CPR method can be a good candidate for distinguishing the phase interactions of ADHD and healthy brain networks. Therefore, this study can contribute to further insights into the nonlinear dynamics analysis of brain networks in ADHD individuals.
测量功能性脑网络中不同脑区之间的相位同步是研究许多心理障碍（如注意力缺陷多动障碍（ADHD））的常用方法。ADHD儿童的情绪处理缺陷是他们社交互动中的主要障碍之一。在本研究中，首次使用递归概率非线性相关（CPR）方法构建了22名患有ADHD的男孩和22名健康男孩在观看四种视觉情绪刺激类型时的功能性脑网络。在ADHD组和健康组中研究了脑网络的拓扑特征，包括最短路径长度、聚类系数和节点强度。结果表明，ADHD个体脑网络的平均聚类系数显著（P值<0.01）高于健康个体，最短路径长度低于健康个体。因此，在ADHD脑网络中，局部和全局尺度上的信息交换均异常多于健康个体，导致该组出现超同步。ADHD脑网络的拓扑改变主要出现在大脑的额叶和枕叶，表明该组在情绪和视觉处理方面的脑功能受损。这项调查表明，CPR方法可能是区分ADHD和健康脑网络相位相互作用的良好候选方法。因此，本研究有助于进一步深入了解ADHD个体脑网络的非线性动力学分析。
