2 型糖尿病与早期胰腺癌 5 年总生存率的关系：一项回顾性队列研究。

Association between type 2 diabetes and 5-year overall survival in early-stage pancreatic cancer: a retrospective cohort study.

机构信息

Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, China.

Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, China.

出版信息

PeerJ. 2022 Dec 12;10:e14538. doi: 10.7717/peerj.14538. eCollection 2022.

DOI:10.7717/peerj.14538

PMID:36530401

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9753753/

Abstract

BACKGROUND

This study examined the association between type 2 diabetes mellitus (T2DM) and 5-year overall survival (OS) in patients with pancreatic cancer (PC).

METHODS

This retrospective cohort study included patients diagnosed with stage I/II PC at Shengjing Hospital of China Medical University from January 2012 to December 2017. All patients had pancreatic ductal adenocarcinoma or its subtypes. The outcome was the 5-year OS rate based on data from the patient charts. Data analysis was performed using SPSS 22.0.

RESULTS

A total of 238 patients were included: 72 with T2DM and 166 without T2DM. There were significant differences in blood glucose levels and OS between the two groups (all < 0.05). The median OS was 11.4 (95% confidence interval CI [8.49-14.31]) months in the T2DM group and 16.3 (95% CI [12.44-20.16], = 0.023) months in the non-T2DM group. After adjustment for confounders, T2DM was an independent factor affecting 5-year OS ( = 0.010). Compared with non-T2DM patients, T2DM patients had a higher risk of death (HR = 1.475, 95% CI [1.096-1.985]).

CONCLUSIONS

T2DM is associated with 5-year OS in patients with PC.

摘要

背景

本研究旨在探讨 2 型糖尿病（T2DM）与胰腺癌（PC）患者 5 年总生存率（OS）之间的关系。

方法

本回顾性队列研究纳入了 2012 年 1 月至 2017 年 12 月在中国医科大学盛京医院诊断为 I/II 期 PC 的患者。所有患者均患有胰腺导管腺癌或其亚型。根据患者病历数据，以 5 年 OS 率为结局。数据分析采用 SPSS 22.0 软件进行。

结果

共纳入 238 例患者：72 例患有 T2DM，166 例无 T2DM。两组间血糖水平和 OS 存在显著差异（均<0.05）。T2DM 组的中位 OS 为 11.4 个月（95%置信区间 [8.49-14.31]），非 T2DM 组为 16.3 个月（95%置信区间 [12.44-20.16]， = 0.023）。校正混杂因素后，T2DM 是影响 5 年 OS 的独立因素（ = 0.010）。与非 T2DM 患者相比，T2DM 患者死亡风险更高（HR=1.475，95%置信区间 [1.096-1.985]）。