Scheithauer B W, Rubinstein L J
Cancer. 1978 Dec;42(6):2744-52. doi: 10.1002/1097-0142(197812)42:6<2744::aid-cncr2820420633>3.0.co;2-l.
This paper reviews 8 personally examined cases of primary meningeal mesenchymal chondrosarcoma and 4 similar cases previously reported by others. The clinicopathologic features of these extraosseous intracranial and intraspinal examples are similar to those of other extraskeletal mesenchymal chondrosarcomas. The tumor occurred most often in the second and third decades, showed a moderate tendency to local recurrence (5 of 12 cases) and occasionally metastasized to the lungs (1 case). Both intracranial and intraspinal tumors occurred with equal frequency, but the former, probably due to the later onset of symptoms, had the worse prognosis. Microscopically, they are composed of primitive undifferentiated mesenchymal cells and frequently well-defined islands of hyaline cartilage. There is an apparent correlation between the frequency of mitotic figures and the likelihood of recurrence and metastasis. Electron microscopic study of one example revealed morphologic features similar to those previously described by others and supports the conclusion that the neoplastic cells represent primitive precartilaginous mesenchyme displaying focal cartilaginous differentiation.
本文回顾了8例经本人检查的原发性脑膜间叶性软骨肉瘤病例以及其他作者先前报道的4例类似病例。这些发生于颅内和椎管内骨骼外的病例的临床病理特征与其他骨骼外间叶性软骨肉瘤相似。肿瘤最常发生于第二和第三个十年，有中度的局部复发倾向（12例中有5例），偶尔转移至肺部（1例）。颅内和椎管内肿瘤的发生率相同，但前者可能由于症状出现较晚，预后较差。显微镜下，它们由原始未分化的间叶细胞组成，并常有界限清楚的透明软骨岛。有丝分裂象的频率与复发和转移的可能性之间存在明显的相关性。对1例病例的电子显微镜研究揭示了与其他作者先前描述的形态特征相似，并支持肿瘤细胞代表显示局灶性软骨分化的原始软骨前间叶这一结论。
