Department of Psychology, Harvard University, 33 Kirkland St, Cambridge, MA, 02138, USA.
Sci Rep. 2022 Dec 19;12(1):21927. doi: 10.1038/s41598-022-25658-5.
Suicide is one of the leading causes of death amongst adolescents and decades of research have failed to curb suicide rates within this population. There is thus a need to better understand factors that correlate with adolescent suicidal thoughts and behaviors (STBs). MDMA/ecstasy and classic psychedelics represent two areas for exploration, as use of these substances has been associated with both increased and lowered odds of STBs. Thus, the goal of this study was to test the associations between MDMA/ecstasy and classic psychedelics (psilocybin, peyote, mescaline, LSD) and STBs in a nationally representative sample of U.S. adolescents. We tested these associations in a sample of adolescents aged 12-17 years old from the National Survey on Drug Use and Health (2004-2019) (N = 262,617) using survey-weighted multivariable logistic regression models. Lifetime psilocybin use was associated with lowered odds of lifetime suicidal thinking, planning, and attempts (aOR range 0.77-0.85). Conversely, LSD was associated with increased odds of these same outcomes (aOR range 1.20-1.35). MDMA/ecstasy, peyote, and mescaline did not share associations with STBs. Our study demonstrates that individual classic psychedelics share varying relationships to STBs among adolescents. Future cross-sectional and longitudinal studies are needed to further elucidate the link between classic psychedelic use and STBs in youth.
自杀是青少年死亡的主要原因之一，几十年来的研究未能遏制这一年轻人群体的自杀率。因此，需要更好地了解与青少年自杀意念和行为（STB）相关的因素。摇头丸/迷幻药和经典迷幻剂代表了两个探索领域，因为这些物质的使用与 STB 的发生几率增加和降低都有关。因此，本研究的目的是在一个具有全国代表性的美国青少年样本中测试摇头丸/迷幻药和经典迷幻剂（裸盖菇素、仙人球毒碱、三甲氧苯乙胺、麦司卡林）与 STB 之间的关联。我们使用调查加权多变量逻辑回归模型，在国家药物使用与健康调查（2004-2019 年）中 12-17 岁的青少年样本（N=262617）中测试了这些关联。一生中使用裸盖菇素与降低一生中自杀想法、计划和尝试的几率相关（比值比范围 0.77-0.85）。相反，LSD 与这些相同结果的几率增加相关（比值比范围 1.20-1.35）。摇头丸/迷幻药、仙人球毒碱和三甲氧苯乙胺与 STB 没有关联。我们的研究表明，个别经典迷幻剂与青少年 STB 之间存在不同的关系。需要进一步进行横断面和纵向研究，以进一步阐明青少年使用经典迷幻剂与 STB 之间的联系。
