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进行性骨化性纤维发育不良:伴颞下颌关节假性强直的 1 例报告。

Fibrodysplasia Ossificans Progressiva: A Case Report with Pseudo-Ankylosis of the Temporomandibular Joint.

机构信息

Cleft and Craniofacial South Australia, Women's and Children's Hospital, North Adelaide, South Australia, Australia.

Division of Plastic Surgery, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

出版信息

Cleft Palate Craniofac J. 2024 May;61(5):897-900. doi: 10.1177/10556656221146598. Epub 2022 Dec 19.

Abstract

Fibrodysplasia ossificans progressiva (FOP) is a rare condition characterized by progressive heterotopic ossifications and congenital hallux valgus deformities. The common underlying genetic cause is an mutation, resulting in altered bone morphogenetic protein (BMP) regulation. Trauma and/or minor procedures aggravate the abnormal bony formation in soft tissues. This report presents a 3-year-old child with this condition who presented pseudo-ankylosis of the temporomandibular joint (TMJ) after minor craniofacial trauma. Abnormal ossification in the medial pterygoid muscle was identified as the causative abnormality for the presentation with trismus.

摘要

进行性骨化性纤维发育不良(FOP)是一种罕见的疾病,其特征为进行性异位骨化和先天性拇外翻畸形。常见的潜在遗传原因是 突变,导致骨形态发生蛋白(BMP)调节异常。创伤和/或小手术会加重软组织中的异常骨形成。本报告介绍了一例 3 岁患儿,在轻度头面部创伤后出现颞下颌关节(TMJ)假性强直。翼内肌异常骨化被确定为导致牙关紧闭的原因。

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