Cao Yang, Xiao Neng, Hu Shiteng, Tang Qiongmei, Zhou Haijun
Department of Radiology, Chenzhou First People's Hospital, University of South China, Chenzhou, People's Republic of China.
Department of Neurology, Chenzhou First People's Hospital, University of South China, Chenzhou, People's Republic of China.
Int J Gen Med. 2022 Dec 13;15:8557-8565. doi: 10.2147/IJGM.S390929. eCollection 2022.
The aim of our study was to investigate the role of three-dimensional arterial spin labeling (3D-ASL) perfusion in the diagnosis and follow-up of children with viral encephalitis.
Twenty-five consecutive children with viral encephalitis and 25 healthy children of similar age were recruited for the study between 2017 and 2020. Conventional magnetic resonance imaging and 3D-ASL were performed for all subjects, and a color map of cerebral blood flow (CBF) was generated. The images were classified into three groups depending on the time points at which the magnetic resonance examinations were conducted, including the initial admission scan, inpatient review, and follow-up review. Clinical, neuroradiologic, and follow-up features were studied.The CBF values of the lesion area in the diseased brain group and the bilateral temporal cortex in the control group were measured and the differences between the two groups were compared.
Perfusion was significantly increased in the acute cerebral disease group, and CBF and normalized cerebral blood flow(nCBF) were significantly higher than in the control group (124.5 vs 70.3 mL/100 g/min, 2.85 vs 1.36). Follow-up revealed that brain tissue perfusion in the lesion area of nine children decreased gradually after treatment, as their condition improved.
Brain tissue perfusion in children with viral encephalitis increases during the acute stage and decreases when the condition improves. 3D-ASL provides a reference for diagnosis and follow-up of viral encephalitis in children.
本研究旨在探讨三维动脉自旋标记（3D-ASL）灌注成像在儿童病毒性脑炎诊断及随访中的作用。
2017年至2020年期间，连续招募了25例病毒性脑炎患儿及25例年龄相仿的健康儿童作为研究对象。对所有受试者均进行了常规磁共振成像及3D-ASL检查，并生成脑血流量（CBF）彩色图。根据磁共振检查的时间点，将图像分为三组，包括初次入院扫描、住院复查及随访复查。对临床、神经放射学及随访特征进行了研究。测量了患病脑组病变区域及对照组双侧颞叶皮质的CBF值，并比较了两组之间的差异。
急性脑病组灌注明显增加，CBF及标准化脑血流量（nCBF）显著高于对照组（124.5 vs 70.3 mL/100 g/min，2.85 vs 1.36）。随访发现，9例患儿治疗后随着病情好转，病变区域脑组织灌注逐渐下降。
病毒性脑炎患儿急性期脑组织灌注增加，病情好转时灌注下降。3D-ASL为儿童病毒性脑炎的诊断及随访提供了参考。
