Tang Shilong, Liu Xianfan, He Ling, Liu Bo, Qin Bin, Feng Chuan
From the Department of Radiology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Critical Disorders, Chongqing, China.
J Comput Assist Tomogr. 2019 Sep/Oct;43(5):697-707. doi: 10.1097/RCT.0000000000000911.
To explore the application value of postlabeling delay (PLD) in 3D pseudocontinuous arterial spin-labeled (3D-pcASL) perfusion imaging in normal children and to find the optimal PLD values for children at each age group.
Five groups of children, with 50 patients in each group, who underwent routine magnetic resonance imaging scans with normal results were included. The patients were stratified according to the following ages: younger than 1 month, more than 1 month to 6 months, more than 6 months to 12 months, more than 1 year to 3 years, more than 3 years to 6 years, and more than 6 years to 18 years. All patients received 3D-pcASL perfusion magnetic resonance scanning. The PLD values were set to 1025, 1525, or 2025 milliseconds. In subjective evaluations, the signal-to-noise ratio (SNR) and cerebral blood flow (CBF) of 3D-pcASL perfusion images under different PLD values were compared and analyzed.
For patients in the <1-month group and >1-month to 6-month group, the images were mainly grade A when the PLD value was 1025 milliseconds, which equaled 43 and 46 cases, respectively. The brain CBF values and SNR values were higher than those of the images with PLD values of 1525 and 2025 milliseconds. For patients in the >6-month to 12-month group, >1-year to 3-year group, >3-year to 6-year group, and >6-year to 18-year group, the images were mainly grade A when the PLD value was 1525 milliseconds, which equaled 43, 45, 43, and 46 cases, respectively. The brain CBF values and SNR values were higher than those of the images with PLD values of 1025 and 2025 milliseconds.
The optimal PLD values for 3D-pcASL perfusion imaging are different in children of different ages. The optimal PLD value for infants who are 6 months younger is 1025 milliseconds. The optimal PLD value for children older than 6 months to 18 years is 1525 milliseconds.
探讨标记后延迟（PLD）在正常儿童三维伪连续动脉自旋标记（3D-pcASL）灌注成像中的应用价值，并找出各年龄组儿童的最佳PLD值。
纳入五组儿童，每组50例，均接受常规磁共振成像扫描且结果正常。根据年龄将患者分为以下几组：小于1个月、大于1个月至6个月、大于6个月至12个月、大于1岁至3岁、大于3岁至6岁、大于6岁至18岁。所有患者均接受3D-pcASL灌注磁共振扫描。PLD值设置为1025、1525或2025毫秒。在主观评估中，比较并分析不同PLD值下3D-pcASL灌注图像的信噪比（SNR）和脑血流量（CBF）。
对于小于1个月组和大于1个月至6个月组的患者，当PLD值为1025毫秒时，图像主要为A级，分别为43例和46例。脑CBF值和SNR值高于PLD值为1525和2025毫秒的图像。对于大于6个月至12个月组、大于1岁至3岁组、大于3岁至6岁组和大于6岁至18岁组的患者，当PLD值为1525毫秒时，图像主要为A级，分别为43例、45例、43例和46例。脑CBF值和SNR值高于PLD值为1025和2025毫秒的图像。
不同年龄儿童3D-pcASL灌注成像的最佳PLD值不同。6个月以下婴儿的最佳PLD值为1025毫秒。6个月至18岁儿童的最佳PLD值为1525毫秒。
