Okamura Yuriko, Nakanishi Rine, Hashimoto Hidenobu, Mizumura Sunao, Homma Sakae, Ikeda Takanori
Department of Cardiovascular Medicine, Toho University Graduate School of Medicine, Tokyo, Japan.
Division of Cardiovascular Medicine, Department of Internal Medicine, Toho University Faculty of Medicine, Tokyo, Japan.
Ann Nucl Cardiol. 2022;8(1):57-66. doi: 10.17996/anc.22-00160. Epub 2022 Aug 31.
: Although F-fluorodeoxyglucose (FDG) positron emission tomography (PET) has been widely utilized to assess the extent of inflammation, the association between the extent and severity of atherosclerosis and F-FDG uptake on PET remains unexamined. The current study aimed to investigate whether aortic calcium (AC) scores were associated with increased aortic uptake of F-FDG on PET. : A total of 167 consecutive patients with suspected lung cancer but unproven malignancy who underwent non-contrast-enhanced computed tomography (CT) and F-FDG PET/CT were enrolled. The average standardized uptake values in the ascending aorta were used to calculate the target-to-background ratio (Mean TBR). The total (thoracic and abdominal) AC scores were measured on non-contrast-enhanced chest and abdominal CT using the Agatston method, and were categorized into three groups (0, 1-399, and ≥400). The relationship between total AC scores and F-FDG uptake in the ascending aorta was assessed using multivariate linear regression analysis. : In total, 68.26% were male, and a mean age was 67.10±14.70 years. Mean TBR values increased progressively with total AC score 0, 1-399, and ≥400 (1.01±0.07, 1.08±0.09, and 1.11±0.11, respectively; p<0.00001). Multivariate linear regression analysis revealed that increased total AC scores of 1-399 (=0.06, 95% CI: 0.01-0.11, p=0.02) and ≥400 (=0.11, 95% CI: 0.06-0.16, p<0.001) were significantly associated with higher Mean TBR. : The current study demonstrated that total AC scores were associated with Mean TBR. Patients with a greater extent and severity of aortic calcifications may possess increased atherosclerotic inflammatory activity as measured by F-FDG PET/CT.
尽管氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）已被广泛用于评估炎症程度，但动脉粥样硬化的范围和严重程度与PET上F-FDG摄取之间的关联仍未得到研究。本研究旨在调查主动脉钙化（AC）评分是否与PET上主动脉F-FDG摄取增加相关。
共纳入167例连续的疑似肺癌但未确诊恶性肿瘤的患者，这些患者接受了非增强计算机断层扫描（CT）和F-FDG PET/CT检查。升主动脉的平均标准化摄取值用于计算靶本底比值（平均TBR）。使用阿加斯顿方法在非增强胸部和腹部CT上测量总（胸段和腹段）AC评分，并将其分为三组（0、1-399和≥400）。使用多变量线性回归分析评估总AC评分与升主动脉F-FDG摄取之间的关系。
总体而言，68.26%为男性，平均年龄为67.10±14.70岁。平均TBR值随着总AC评分0、1-399和≥400而逐渐增加（分别为1.01±0.07、1.08±0.09和1.11±0.11；p<0.00001）。多变量线性回归分析显示，总AC评分增加至1-399（β=0.06，95%CI：0.01-0.11，p=0.02）和≥400（β=0.11，95%CI：0.06-0.16，p<0.001）与更高的平均TBR显著相关。
本研究表明，总AC评分与平均TBR相关。主动脉钙化范围和严重程度更大的患者，通过F-FDG PET/CT测量可能具有增加的动脉粥样硬化炎症活动。
