Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.
Department of Community Mental Health in Mild Intellectual Disabilities, Trajectum, Zutphen, The Netherlands.
Eur Psychiatry. 2022 Dec 21;66(1):e7. doi: 10.1192/j.eurpsy.2022.2355.
Women with triple X syndrome (TXS) have an extra X chromosome. TXS appeared to be associated with psychiatric disorders in biased or underpowered studies.
This study aims to describe the prevalence of psychiatric disorders in adults with TXS in a relatively large and less biased group of participants.
In this cross-sectional study, data were collected from 34 women with TXS (mean age = 32.9; s.d. = 13.1) and 31 controls (mean age = 34.9; s.d. = 13.7). Psychiatric disorders were assessed using the MINI International Neuropsychiatric Interview (MINI) and the adult behavior checklist (ABCL). Trait and state anxiety were assessed using the State-Trait Anxiety Inventory.
In the TXS group, MINI results showed a higher prevalence of major depressive episodes (43.3%), psychotic disorders (29.4%), and suicidality (23.5%). Only 50% of the TXS group earned a normal score for the total syndrome score using the ABCL. In addition, levels of trait anxiety were higher in the TXS group. Only three women in each group received psychotropic medication. Impaired social functioning appeared to represent a major risk factor in TXS as regards psychotic, affective disorders, trait anxiety, and low self-esteem.
Women with TXS are vulnerable to developing psychiatric disorders, and women with both TXS and impaired social functioning are even more vulnerable.
患有三 X 综合征（TXS）的女性有一条额外的 X 染色体。TXS 似乎与精神障碍有关，但在有偏差或效力不足的研究中。
本研究旨在描述在相对较大且偏差较小的一组参与者中，TXS 成年患者的精神障碍患病率。
在这项横断面研究中，从 34 名 TXS 女性（平均年龄=32.9；标准差=13.1）和 31 名对照者（平均年龄=34.9；标准差=13.7）中收集数据。使用 MINI 国际神经精神病学访谈（MINI）和成人行为检查表（ABCL）评估精神障碍。使用状态-特质焦虑量表评估特质和状态焦虑。
在 TXS 组中，MINI 结果显示，重度抑郁发作（43.3%）、精神病性障碍（29.4%）和自杀意念（23.5%）的患病率较高。仅 50%的 TXS 组在 ABCL 总分中获得正常评分。此外，TXS 组的特质焦虑水平较高。只有每组中的 3 名女性接受了精神药物治疗。受损的社会功能似乎是 TXS 患者发生精神病、情感障碍、特质焦虑和低自尊的主要危险因素。
患有 TXS 的女性易患精神障碍，而同时患有 TXS 和受损社会功能的女性则更容易患病。
