Department of Pathology, Stanford University, Stanford, CA 94305, USA,
Pac Symp Biocomput. 2023;28:549-553.
In cancer, complex ecosystems of interacting cell types play fundamental roles in tumor development, progression, and response to therapy. However, the cellular organization, community structure, and spatially defined microenvironments of human tumors remain poorly understood. With the emergence of new technologies for high-throughput spatial profiling of complex tissue specimens, it is now possible to identify clinically significant spatial features with high granularity. In this PSB workshop, we will highlight recent advances in this area and explore how single cell spatial profiling can advance precision cancer medicine.
在癌症中，相互作用的细胞类型的复杂生态系统在肿瘤的发生、发展和对治疗的反应中起着基础性的作用。然而，人类肿瘤的细胞组织、群落结构和空间定义的微环境仍然知之甚少。随着高通量空间分析复杂组织标本的新技术的出现，现在有可能以高分辨率识别具有临床意义的空间特征。在本次 PSB 研讨会上，我们将重点介绍这一领域的最新进展，并探讨单细胞空间分析如何推动精准癌症医学的发展。
