Kochar M S, Zeller J R, Itskovitz H D
Clin Pharmacol Ther. 1979 Feb;25(2):143-8. doi: 10.1002/cpt1979252143.
The efficacy of prazosin was assessed in 21 patients with essential hypertension who failed to respond adequately to a combination of methyldopa and hydrochlorothiazide. The patients were divided randomly into two groups; in the first group prazosin was substituted for methyldopa and in the second group prazosin was added to the combination. In group 1, the average blood pressure (BP) fell from 144/102 mmHg (sitting) and 142/105 mmHg (standing) to 136/91 mmHg (sitting) and 129/91 mmHg (standing) after prazosin (17 mg) was substituted for methyldopa. The fall in the diastolic BP was statistically significant (p less than 0.01). In group 2, BP fell from 146/101 mmHg (sitting) and 143/103 mmHg (standing) to 126/87 mmHg (sitting) and 118/86 mmHg (standing) when prazosin 14 mg was added to methyldopa and hydrochlorothiazide. The reductions in systolic and diastolic pressures were statistically significant (p less than 0.001).
对21例原发性高血压患者进行了哌唑嗪疗效评估，这些患者对甲基多巴和氢氯噻嗪联合用药反应欠佳。患者被随机分为两组；第一组用哌唑嗪替代甲基多巴，第二组在联合用药基础上加用哌唑嗪。在第一组中，用哌唑嗪（17毫克）替代甲基多巴后，平均血压（BP）从坐位时的144/102毫米汞柱和立位时的142/105毫米汞柱降至坐位时的136/91毫米汞柱和立位时的129/91毫米汞柱。舒张压下降具有统计学意义（p<0.01）。在第二组中，当在甲基多巴和氢氯噻嗪基础上加用14毫克哌唑嗪时，血压从坐位时的146/101毫米汞柱和立位时的143/103毫米汞柱降至坐位时的126/87毫米汞柱和立位时的118/86毫米汞柱。收缩压和舒张压的降低具有统计学意义（p<0.001）。
