Whelton P K, Russell R P, Sova-Schulz K, Wyndham R, Walker W G
J Cardiovasc Pharmacol. 1979 Nov-Dec;1(6 Suppl):S28-37.
The value of prazosin and methyldopa administration was compared in 16 patients with essential hypertension during a 6 month randomized, double-blind, parallel trial. Both drugs were administered in combination with hydrochlorothiazide, 50 mg twice daily, until recumbent diastolic blood pressure was decreased to less than 90 mm Hg or the patient was receiving prazosin, 5 mg q.i.d., or methylodpa, 500 mg q.i.d. Addition of either prazosin or methyldopa to hydrochlorothiazide lowered blood pressure significantly and to a similar degree without altering plasma renin activity. Heart rate and weight were significantly increased during prazosin, but not methyldopa, therapy. Symptomatic side effects occurred with equal frequency during treatment with both agents and did not result in alteration or discontinuation of therapy in any patient. A decrease in frequency of administration from q.i.d. to b.i.d. or t.i.d./b.i.d. to q.d. did not adversely affect blood pressure control. Substitution of propranolol for prazosin or methyldopa provided similar antihypertensive effectiveness with a significant decrease in heart rate.
在一项为期6个月的随机、双盲、平行试验中，对16例原发性高血压患者比较了哌唑嗪和甲基多巴的治疗效果。两种药物均与氢氯噻嗪联合使用，氢氯噻嗪每日两次，每次50mg，直至卧位舒张压降至90mmHg以下，或患者接受哌唑嗪每日4次，每次5mg，或甲基多巴每日4次，每次500mg。在氢氯噻嗪基础上加用哌唑嗪或甲基多巴均可显著降低血压，且降低程度相似，同时不改变血浆肾素活性。在哌唑嗪治疗期间，心率和体重显著增加，但甲基多巴治疗期间未出现这种情况。两种药物治疗期间出现症状性副作用的频率相同，且未导致任何患者改变治疗方案或停药。给药频率从每日4次减至每日2次，或从每日2次/每日3次减至每日1次，对血压控制无不利影响。用普萘洛尔替代哌唑嗪或甲基多巴可提供相似的降压效果，同时心率显著降低。
