[采用腹膜切除术联合腹腔内热灌注化疗治疗的伴有恶性分化的成熟畸胎瘤]
[Mature teratoma with malignant differentiation treated with peritonectomy with HIPEC].
作者信息
Peña-Arriaga Magaly Denise, Ramírez-Salado Diana Paola, Ramírez-González Laura Denisse, Martínez-Gómez Héctor, Ruiz Esparza-Garrido Ruth
机构信息
Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Oncología, Servicio de Tumores Ginecológicos. Ciudad de México, México.
Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Oncología, Servicio de Patología. Ciudad de México, México.
出版信息
Rev Med Inst Mex Seguro Soc. 2023 Jan 2;61(1):111-116.
BACKGROUND
Mature teratomas belong to the group of germ line ovarian tumors; they generally have benign behavior. Malignant transformation occurs in 0.2% to 1% of tumors. The objective is to show the results of peritonectomy with HIPEC in the treatment of a mature teratoma with malignant differentiation with signet ring cells.
CLINICAL CASE
43-year-old woman diagnosed with mature malignant teratoma with signet ring cells. It was performed optimal primary cytoreduction surgery, total hysterectomy, bilateral salpingo-oophorectomy, peritonectomy, appendectomy, cholecystectomy and splenectomy adding intraoperative hyperthermic chemotherapy (HIPEC).
CONCLUSIONS
Malignant transformation of a mature teratoma of the ovary is a rare event, but not exceptional. HIPEC was used after optimal cytoreduction, with good results, since the patient is in a disease-free period of 36 months. It is necessary to report cases in order to compare different types of treatment to improve oncological results.
背景
成熟畸胎瘤属于生殖系卵巢肿瘤；它们通常表现为良性。0.2%至1%的肿瘤会发生恶性转化。目的是展示腹腔切除术联合腹腔内热灌注化疗（HIPEC）治疗伴有印戒细胞的成熟畸胎瘤伴恶性分化的效果。
临床病例
一名43岁女性被诊断为伴有印戒细胞的成熟恶性畸胎瘤。进行了最佳的初次细胞减灭术、全子宫切除术、双侧输卵管卵巢切除术、腹腔切除术、阑尾切除术、胆囊切除术和脾切除术，并加行了术中热化疗（HIPEC）。
结论
卵巢成熟畸胎瘤的恶性转化是一种罕见事件，但并非罕见。在最佳细胞减灭术后使用了HIPEC，效果良好，因为该患者处于36个月的无病期。有必要报告病例，以便比较不同类型的治疗方法以改善肿瘤治疗效果。
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