Wang Xiangyu, Li Wenjing, Kong Yan, Liu Xiangyu, Cui Zhumei
235960The Affiliated Hospital of Qingdao University, Department of Gynecology, Qingdao, China.
J Int Med Res. 2021 Feb;49(2):300060520981549. doi: 10.1177/0300060520981549.
This study aimed to examine the clinicopathological characteristics, treatment, and prognostic factors in 12 cases of malignant transformation of mature cystic teratoma of the ovary (MCTO).
We performed a retrospective study of 12 patients with malignant transformation of MCTO who were admitted to the Affiliated Hospital of Qingdao University from 2003 to 2019. We examined case records, clinical parameters, and biological assessments.
The median age of the patients was 56.5 years and seven of them were postmenopausal. The average tumor size was 18.5 cm. All patients had pelvic masses at their first hospital visit. Nine of the patients had discomfort in the lower abdomen, two presented with a lower abdominal palpable mass, and three were complicated by fever. The median follow-up time was 73 months (12‒193 months). Ten patients survived with a disease-free status and two died.
There is a low incidence of malignant transformation of MCTO, and its most common histological type is squamous cell carcinoma. Age and tumor size are important factors in malignant transformation of teratomas. While there is a lack of treatment guidelines for malignant transformation of MCTO, early diagnosis and treatment may be beneficial for these patients.
本研究旨在探讨12例卵巢成熟囊性畸胎瘤（MCTO）恶变的临床病理特征、治疗及预后因素。
我们对2003年至2019年期间入住青岛大学附属医院的12例MCTO恶变患者进行了回顾性研究。我们检查了病例记录、临床参数和生物学评估。
患者的中位年龄为56.5岁，其中7例为绝经后患者。肿瘤平均大小为18.5 cm。所有患者首次就诊时均有盆腔肿块。9例患者有下腹部不适，2例可触及下腹部肿块，3例伴有发热。中位随访时间为73个月（12 - 193个月）。10例患者存活且无疾病状态，2例死亡。
MCTO恶变的发生率较低，其最常见的组织学类型为鳞状细胞癌。年龄和肿瘤大小是畸胎瘤恶变的重要因素。虽然目前缺乏MCTO恶变的治疗指南，但早期诊断和治疗可能对这些患者有益。
