Kunkle G A, Meyer D J
Department of Medical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610.
J Am Vet Med Assoc. 1987 Aug 1;191(3):322-3.
Eight adult cats were treated with griseofulvin (110 to 145 mg/kg of body weight) daily for 11 weeks; 2 control cats were given a gelatin capsule daily. Hemograms and hepatic enzyme activities were monitored weekly for all cats. Bone marrow examinations were performed before administration of the drug and twice during the study. Cats were observed for untoward clinical effects. Signs of toxicosis (clinical, hematologic, or hepatic) were not found at any time during, or at the cessation of, the study. Although the sample number of treated cats was small, it was concluded that hematologic or hepatic abnormalities that develop with the use of high-dose griseofulvin treatment may be an idiosyncratic reaction found only in a few cats.
八只成年猫每天接受灰黄霉素治疗（110至145毫克/千克体重），持续11周；两只对照猫每天给予一粒明胶胶囊。每周对所有猫进行血常规和肝酶活性监测。在给药前和研究期间进行两次骨髓检查。观察猫是否有不良临床效应。在研究期间或结束时的任何时候均未发现中毒迹象（临床、血液学或肝脏方面）。尽管接受治疗的猫的样本数量较少，但得出的结论是，使用高剂量灰黄霉素治疗时出现的血液学或肝脏异常可能是仅在少数猫中发现的特异反应。
