被诊断为重度抑郁症的青少年血清Apelin-13水平降低。
Serum Apelin-13 Levels Are Decreased Among Adolescents Diagnosed with Major Depressive Disorder.
作者信息
Acikel Sadettin Burak, Artik Abdulbaki, Hosoglu Esra, Yerlikaya Fatma Hümeyra
机构信息
Ankara University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Ankara, Turkey,
出版信息
Psychiatr Danub. 2022 Winter;34(4):677-681. doi: 10.24869/psyd.2022.677.
BACKGROUND
Apelin-13 have potential effect on mood because of high expression in the hypothalamus. In this study, we aimed to investigate the serum apelin-13 levels among adolescents with major depressive disorder.
SUBJECT AND METHODS
A total of 42 patients between the ages of 12 and 18 with a primary diagnosis of major depressive disorder have been included. Depression scores of both groups were measured by the Children's Depression Inventory. Serum apelin-13 concentrations were measured by a commercially available kit based on enzyme-linked immunosorbent assay (ELISA) method.
RESULTS
The mean serum apelin-13 levels in the patients with MDD was 173.08±106.33 pg/ml, whereas it was 251.75±167.82 pg/ml in healthy controls. The difference between groups in terms of mean serum apelin-13 levels was statistically significant (p=0.018, Cohen's d=-0.571).
CONCLUSION
This is the first study to examine the serum apelin-13 levels in adolescents diagnosed with major depressive disorder. Lower serum apelin-13 levels were found in depressed adolescents.
背景
Apelin-13在下丘脑中高表达，对情绪可能有潜在影响。在本研究中，我们旨在调查重度抑郁症青少年的血清Apelin-13水平。
对象与方法
纳入42例年龄在12至18岁之间、初步诊断为重度抑郁症的患者。两组的抑郁评分均采用儿童抑郁量表进行测量。血清Apelin-13浓度采用基于酶联免疫吸附测定（ELISA）方法的商用试剂盒进行测量。
结果
重度抑郁症患者的血清Apelin-13平均水平为173.08±106.33 pg/ml，而健康对照组为251.75±167.82 pg/ml。两组间血清Apelin-13平均水平的差异具有统计学意义（p = 0.018，Cohen's d = -0.571）。
结论
这是第一项研究诊断为重度抑郁症的青少年血清Apelin-13水平的研究。抑郁青少年的血清Apelin-13水平较低。
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