Ng Ding Quan, Jia Stanley, Wisseh Cheryl, Cadiz Christine, Nguyen Megan, Lee Joyce, McBane Sarah, Nguyen Lee, Chan Alexandre, Hurley-Kim Keri
J Am Pharm Assoc (2003). 2023 Mar-Apr;63(2):582-591.e20. doi: 10.1016/j.japh.2022.11.005. Epub 2022 Nov 13.
The National Institutes of Health All of Us (AoU) Research Program is currently building a database of 1million+ adult subjects. With it, we describe the characteristics of those with documented vaccinations.
To describe the sociodemographic, health status, and lifestyle factors associated with vaccinations.
This is a retrospective study involving data from the AoU program (R2020Q4R2, N = 315,297). Five vaccine cohorts [influenza, hepatitis B (HBV), pneumococcal <65 years old, pneumococcal ≥65 years old, and human papillomavirus (HPV)] were generated based on vaccination history. The influenza cohort comprised participants with documented influenza vaccinations in electronic health records (EHRs) from September 2017 to May 2018. Other vaccine cohorts comprised participants with ≥1 lifetime record(s) of vaccination documented in the EHR by December 2018. The vaccine cohorts were compared to the overall AoU cohort. Descriptive statistics were generated using EHR- and survey-based sociodemographic, health, and lifestyle information. The SAMBA (0.9.0) R package was utilized to adjust for EHR selection and outcome misclassification biases to infer sources of disparity for pneumococcal vaccinations in older adults.
Cohort counts were as follows: influenza (n = 15,346), HBV (n = 6323), pneumococcal <65 (n = 15,217), pneumococcal ≥65 (n = 15,100), and HPV (n = 2125). All vaccine cohorts had higher proportions of White and non-Hispanic/Latino participants compared to the overall AoU cohort. The largest differences were found in pneumococcal age ≥65, with 80.2% White participants compared to 52.9% in the overall study population. Multivariable analysis revealed that race/ethnic disparities in pneumococcal vaccination among older adults were explained by biological sex, income, health insurance, and education-related variables.
Racial, ethnic, education, and income characteristics differ across the vaccine cohorts among AoU participants. These findings inform future utilization of large health databases in vaccine epidemiology research and emphasize the need for more targeted interventions that address differences in vaccine uptake.
美国国立卫生研究院“我们所有人”（AoU）研究项目目前正在建立一个包含100多万成年受试者的数据库。在此基础上，我们描述了有疫苗接种记录者的特征。
描述与疫苗接种相关的社会人口学、健康状况和生活方式因素。
这是一项回顾性研究，涉及AoU项目的数据（R2020Q4R2，N = 315,297）。根据疫苗接种史生成了五个疫苗队列[流感、乙型肝炎（HBV）、65岁以下肺炎球菌、65岁及以上肺炎球菌和人乳头瘤病毒（HPV）]。流感队列包括2017年9月至2018年5月电子健康记录（EHR）中有流感疫苗接种记录的参与者。其他疫苗队列包括截至2018年12月EHR中有≥1次终生疫苗接种记录的参与者。将疫苗队列与整个AoU队列进行比较。使用基于EHR和调查的社会人口学、健康和生活方式信息生成描述性统计数据。利用SAMBA（0.9.0）R包调整EHR选择和结果误分类偏差，以推断老年人肺炎球菌疫苗接种差异的来源。
各队列人数如下：流感（n = 15,346）、HBV（n = 6323）、65岁以下肺炎球菌（n = 15,217）、65岁及以上肺炎球菌（n =
