基层医疗抗菌药物管理计划对尿路感染细菌耐药性控制及生态印记的影响
Impact of a Primary Care Antimicrobial Stewardship Program on Bacterial Resistance Control and Ecological Imprint in Urinary Tract Infections.
作者信息
Jover-Sáenz Alfredo, Ramírez-Hidalgo María, Bellés Bellés Alba, Ribes Murillo Esther, Batlle Bosch Meritxell, Cayado Cabanillas José, Garrido-Calvo Sònia, Gracia Vilas María Isabel, Gros Navés Laura, Javierre Caudevilla María Jesús, Mari López Alba, Montull Navarro Lidia, Ortiz Valls Mireia, Terrer Manrique Gemma, Vaqué Castilla Pilar, Ichart Tomás José Javier, Justribó Sánchez Elena, Andreu Mayor Ester, Carrera Guiu Joan, Martorell Solé Roser, Pallàs Satué Silvia, Saura Codina Mireia, Vena Martínez Ana, Albalat Samper José Manuel, Cano Marrón Susana, Chacón Domínguez Isabel, Escuin David de la Rica, Estadella Servalls María José, Figueres Farreny Ana M, Minguet Vidal Sonia, Montaña Esteban Luís Miguel, Otal Bareche Josep, Pallerola Planes Mercè, Pujol Aymerich Francesc, Rodríguez Garrocho Andrés, Solé Curcó Antoni, Toribio Redondo Francisca, Urgelés Castillón María Cruz, Valgañon Palacios Juan, Torres-Puig-Gros Joan
机构信息
Unidad Territorial Infección Nosocomial (UTIN), Hospital Universitari Arnau de Vilanova de Lleida (HUAV), Institut de Recerca Biomèdica (IRBLleida), 25198 Lleida, Spain.
Sección de Microbiología, HUAV, 25198 Lleida, Spain.
出版信息
Antibiotics (Basel). 2022 Dec 8;11(12):1776. doi: 10.3390/antibiotics11121776.
Antimicrobial stewardship programs (ASPs) are a central component in reducing the overprescription of unnecessary antibiotics, with multiple studies showing benefits in the reduction of bacterial resistance. Less commonly, ASPs have been performed in outpatient settings, but there is a lack of available data in these settings. We implemented an ASP in a large regional outpatient setting to assess its feasibility and effectiveness. Over a 5-year post-implementation period, compared to the pre-intervention period, a significant reduction in antibiotic prescription occurred, with a reduction in resistance in urinary isolates. ASP activities also were found to be cost-effective, with a reduction in medication prescription.
抗菌药物管理计划（ASPs）是减少不必要抗生素过度处方的核心组成部分，多项研究表明其在降低细菌耐药性方面具有益处。在门诊环境中实施抗菌药物管理计划的情况较少见，且这些环境中缺乏可用数据。我们在一个大型区域门诊环境中实施了一项抗菌药物管理计划，以评估其可行性和有效性。在实施后的5年期间，与干预前相比，抗生素处方显著减少，尿液分离株中的耐药性降低。抗菌药物管理计划活动还被发现具有成本效益，药物处方有所减少。
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