对从巴西亚马逊地区家禽中分离出的同时产生KPC-2和CTX-M-14的ST258菌株的基因组分析。
Genomic Analysis of ST258 Strain Coproducing KPC-2 and CTX-M-14 Isolated from Poultry in the Brazilian Amazon Region.
作者信息
Valiatti Tiago Barcelos, Cayô Rodrigo, Santos Fernanda Fernandes, Bessa-Neto Francisco Ozório, Brandão Silva Ramon Giovani, Veiga Ruanita, de Nazaré Miranda Bahia Márcia, Guerra Lívia Maria Guimarães Dutra, Pignatari Antônio Carlos Campos, de Oliveira Souza Cintya, Brasiliense Danielle Murici, Gales Ana Cristina
机构信息
Laboratório Alerta, Disciplina Infectologia, Departamento de Medicina, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo 04039-032, SP, Brazil.
Laboratório de Imunologia e Microbiologia (LIB), Setor de Biologia Molecular, Microbiologia e Imunologia, Departamento de Ciências Biológicas (DCB), Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF), Universidade Federal de São Paulo (UNIFESP), Diadema 09972-270, SP, Brazil.
出版信息
Antibiotics (Basel). 2022 Dec 17;11(12):1835. doi: 10.3390/antibiotics11121835.
This study aimed to characterize a strain (KP411) recovered from the stool samples of poultry () in the Brazilian Amazon Region. The whole-genome sequencing of KP411 revealed the presence of an important arsenal of antimicrobial resistance genes to β-lactams (, , , ), aminoglycosides [], sulfonamides (), quinolones (), fosfomycin (), and macrolides []. Furthermore, our analyses revealed that the KP411 strain belongs to the ST258 clonal lineage, which is one of the main epidemic clones responsible for the dissemination of KPC-2 worldwide. Our data suggest that food-producing animals may act as reservoirs of multidrug-resistant belonging to the ST258 clone, and, consequently, contribute to their dissemination to humans and the environment.
本研究旨在对从巴西亚马逊地区家禽粪便样本中分离出的一株菌株（KP411）进行特征描述。KP411的全基因组测序显示，其存在针对β-内酰胺类（blaCTX-M、blaTEM、blaSHV、blaKPC）、氨基糖苷类（aac(6’)-Ib-cr）、磺胺类（sul1）、喹诺酮类（qnrS）、磷霉素（fosA）和大环内酯类（ermB）的重要抗菌药物耐药基因库。此外，我们的分析表明，KP411菌株属于ST258克隆谱系，这是导致KPC-2在全球传播的主要流行克隆之一。我们的数据表明，产食动物可能作为ST258克隆多重耐药肺炎克雷伯菌的储存宿主，从而促使其传播至人类和环境。
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