Osowska Sylwia, Kunecki Marek, Sobocki Jacek, Tokarczyk Joanna, Majewska Krystyna, Burkacka Magdalena, Radkowski Marek, Makarewicz-Wujec Magdalena, Fisk Helena L, Mashnafi Sultan, Baumgartner Sabine, Plat Jogchum, Calder Philip C
Applied Pharmacy Department, Warsaw Medical University, 02-097 Warsaw, Poland.
Centre of Clinical Nutrition, Pirogow Hospital, 90-531 Lodz, Poland.
Biology (Basel). 2022 Nov 24;11(12):1699. doi: 10.3390/biology11121699.
the effect on liver function markers and inflammation of the different content of phytosterols in lipid emulsions (LEs) used in the parenteral nutrition (PN) regimen of adult home PN (HPN) patients is not clear.
plasma phytosterol and cytokine concentrations, fatty acid composition, liver function markers, and triglycerides were measured in 58 adult HPN patients receiving one of three different LEs (soybean oil-based: Intralipid; olive oil-based: ClinOleic; containing fish oil: SMOFLipid).
patients receiving Intralipid had higher plasma campesterol and stigmasterol concentrations than those receiving ClinOleic or SMOFLipid. Plasma sterol concentrations were not different between patients receiving ClinOleic and SMOFLipid. Differences in plasma fatty acids reflected the fatty acid composition of the LEs. Markers of liver function did not differ among the three groups. Blood triglycerides were higher with ClinOleic than with Intralipid or SMOFLipid. Total bilirubin correlated positively with the plasma concentrations of two of the phytosterols, ALT correlated positively with one, AST with one, and GGT with three.
liver function markers correlate with plasma plant sterol concentrations in adult HPN patients. Adult HPN patients receiving SMOFLipid are more likely to have liver function markers and triglycerides within the normal range than those receiving ClinOleic or Intralipid. The omega-3 fatty acids in SMOFLipid may act to mitigate the adverse effects of plant sterols on liver function.
在成人家庭肠外营养（HPN）患者的肠外营养（PN）方案中，脂质乳剂（LEs）中不同含量的植物甾醇对肝功能指标和炎症的影响尚不清楚。
对58例接受三种不同LEs之一（大豆油基：英脱利匹特；橄榄油基：克列诺油酸；含鱼油：SMOFLipid）的成人HPN患者，测定其血浆植物甾醇和细胞因子浓度、脂肪酸组成、肝功能指标及甘油三酯。
接受英脱利匹特的患者血浆菜油甾醇和豆甾醇浓度高于接受克列诺油酸或SMOFLipid的患者。接受克列诺油酸和SMOFLipid的患者血浆甾醇浓度无差异。血浆脂肪酸的差异反映了LEs的脂肪酸组成。三组患者的肝功能指标无差异。克列诺油酸组的血甘油三酯高于英脱利匹特组或SMOFLipid组。总胆红素与两种植物甾醇的血浆浓度呈正相关，谷丙转氨酶与一种植物甾醇呈正相关，谷草转氨酶与一种植物甾醇呈正相关，γ-谷氨酰转移酶与三种植物甾醇呈正相关。
成人HPN患者的肝功能指标与血浆植物甾醇浓度相关。与接受克列诺油酸或英脱利匹特的患者相比，接受SMOFLipid的成人HPN患者更有可能使肝功能指标和甘油三酯处于正常范围内。SMOFLipid中的ω-3脂肪酸可能起到减轻植物甾醇对肝功能的不良影响的作用。
