血红素加氧酶-1作为免疫调节剂在肾脏疾病中的作用

The Role of Heme Oxygenase-1 as an Immunomodulator in Kidney Disease.

作者信息

Athanassiadou Virginia, Plavoukou Stella, Grapsa Eirini, Detsika Maria G

机构信息

Department of Nephrology, School of Medicine, National and Kapodistrian University of Athens, Aretaieion University Hospital, 11528 Athens, Greece.

1st Department of Critical Care Medicine & Pulmonary Services, GP Livanos and M Simou Laboratories, Evangelismos Hospital, National and Kapodistrian University of Athens, 10675 Athens, Greece.

出版信息

Antioxidants (Basel). 2022 Dec 13;11(12):2454. doi: 10.3390/antiox11122454.

DOI:10.3390/antiox11122454

PMID:36552662

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9774641/

Abstract

The protein heme oxygenase (HO)-1 has been implicated in the regulations of multiple immunological processes. It is well known that kidney injury is affected by immune mechanisms and that various kidney-disease forms may be a result of autoimmune disease. The current study describes in detail the role of HO-1 in kidney disease and provides the most recent observations of the effect of HO-1 on immune pathways and responses both in animal models of immune-mediated disease forms and in patient studies.

摘要

蛋白质血红素加氧酶（HO）-1参与多种免疫过程的调节。众所周知，肾损伤受免疫机制影响，多种肾病形式可能是自身免疫性疾病的结果。本研究详细描述了HO-1在肾病中的作用，并提供了关于HO-1在免疫介导疾病形式的动物模型和患者研究中对免疫途径及反应影响的最新观察结果。