组织蛋白酶在胶质母细胞瘤中触发细胞死亡并调节放射抵抗性。
Cathepsins Trigger Cell Death and Regulate Radioresistance in Glioblastoma.
机构信息
School of Public Health and Management, Wenzhou Medical University, Wenzhou 325035, China.
South Zhejiang Institute of Radiation Medicine and Nuclear Technology, Wenzhou 325800, China.
出版信息
Cells. 2022 Dec 17;11(24):4108. doi: 10.3390/cells11244108.
Treatment of glioblastoma (GBM) remains very challenging, and it is particularly important to find sensitive and specific molecular targets. In this work, we reveal the relationship between the expression of cathepsins and radioresistance in GBM. We analyzed cathepsins (cathepsin B, cathepsin D, cathepsin L, and cathepsin Z/X), which are highly associated with the radioresistance of GBM by regulating different types of cell death. Cathepsins could be potential targets for GBM treatment.
胶质母细胞瘤（GBM）的治疗仍然极具挑战性，因此找到敏感和特异的分子靶点尤为重要。在这项工作中，我们揭示了组织蛋白酶的表达与 GBM 放射抵抗之间的关系。我们分析了组织蛋白酶（组织蛋白酶 B、组织蛋白酶 D、组织蛋白酶 L 和组织蛋白酶 Z/X），它们通过调节不同类型的细胞死亡与 GBM 的放射抵抗高度相关。组织蛋白酶可能是 GBM 治疗的潜在靶点。
Zotero 插件