Division of Pulmonary, Critical Care and Sleep, University of Arizona, 475 N 5th Street, Phoenix, AZ 85004, USA.
Department of Internal Medicine, College of Medicine-Phoenix, University of Arizona, 475 N 5th Street, Phoenix, AZ 85004, USA.
Genes (Basel). 2022 Dec 6;13(12):2301. doi: 10.3390/genes13122301.
The endothelium is a monolayer of cells lining the inner blood vessels. Endothelial cells (ECs) play indispensable roles in angiogenesis, homeostasis, and immune response under normal physiological conditions, and their dysfunction is closely associated with pathologies such as cardiovascular diseases. Abnormal EC metabolism, especially dysfunctional fatty acid (FA) metabolism, contributes to the development of many diseases including pulmonary hypertension (PH). In this review, we focus on discussing the latest advances in FA metabolism in ECs under normal and pathological conditions with an emphasis on PH. We also highlight areas of research that warrant further investigation.
内皮细胞是衬在内脏血管内壁的单层细胞。在正常生理条件下，内皮细胞（EC）在血管生成、稳态和免疫反应中发挥着不可或缺的作用，其功能障碍与心血管疾病等疾病密切相关。异常的 EC 代谢，特别是功能失调的脂肪酸（FA）代谢，导致包括肺动脉高压（PH）在内的许多疾病的发生。在这篇综述中，我们重点讨论了在正常和病理条件下 EC 中 FA 代谢的最新进展，特别强调了 PH。我们还强调了一些需要进一步研究的研究领域。
