Andrade V L, Marques A B, da Cunha L H, Avelleira J R
Curupaiti State Hospital, Rio de Janeiro, Brazil.
Int J Lepr Other Mycobact Dis. 1987 Sep;55(3):435-40.
The acceptance of the WHO regimen in a group of 220 patients was approximately 84.5%. Only 11% abandoned the treatment, and the substitution of ethionamide or prothionamide for clofazimine due to excessive hyperpigmentation was necessary in only eight cases. The WHO regimens adopted provided a more frequent (monthly) relationship between the patients and their health service. It was necessary to: a) reorganize the technical-administrative infrastructure, with the intention of providing an improved service to the patients for treatment and control; and b) pay more attention to the problem of deformities and health education activities. As for the side effects of the drugs, 54 patients showed alterations in their liver function tests, which were usually mild and which resolved despite continuation of the treatment. Of the reactional episodes observed during MDT, it would not appear that the therapeutic regimens contributed to their occurrence or aggravation.
在一组220名患者中，对世卫组织治疗方案的接受率约为84.5%。只有11%的患者放弃治疗，仅8例患者因色素沉着过度而需要用乙硫异烟胺或丙硫异烟胺替代氯法齐明。所采用的世卫组织治疗方案使患者与卫生服务机构之间的联系更为频繁（每月一次）。有必要：a）重组技术行政基础设施，以便为患者提供更好的治疗和控制服务；b）更加关注畸形问题和健康教育活动。至于药物的副作用，54名患者的肝功能检查出现变化，这些变化通常较轻，尽管继续治疗仍得以缓解。在多药治疗期间观察到的反应性发作中，治疗方案似乎并未导致其发生或加重。
