McGraw T P, Swanborg R H
Eur J Immunol. 1978 Dec;8(12):905-9. doi: 10.1002/eji.1830081215.
Lewis rats with experimental allergic encephalomyelitis (EAE) exhibited cell-mediated immunity to myelin basic protein as determined both with in vivo and in vitro assays. Positive skin test reactions and production of migration inhibitory factor (MIF) were observed before onset and after recovery from EAE. Rats rendered unresponsive to EAE exhibited in vitro cell-mediated immunity to basic protein, although in vivo manifestations were depressed. However, tolerant rats failed to respond to the encephalitogenic determinant; rats with EAE exhibited cell-mediated immunity to this region of the molecule. The results indicate that EAE-unresponsive rats possess lymphocytes capable of responding to basic protein, but that reactivity to the encephalitogenic peptide is suppressed.
患有实验性变态反应性脑脊髓炎（EAE）的Lewis大鼠，通过体内和体外试验测定，均表现出对髓鞘碱性蛋白的细胞介导免疫。在EAE发病前和恢复后均观察到阳性皮肤试验反应和迁移抑制因子（MIF）的产生。对EAE无反应的大鼠在体外表现出对碱性蛋白的细胞介导免疫，尽管体内表现受到抑制。然而，耐受大鼠对致脑炎决定簇无反应；患有EAE的大鼠对该分子区域表现出细胞介导免疫。结果表明，对EAE无反应的大鼠拥有能够对碱性蛋白作出反应的淋巴细胞，但对致脑炎肽的反应性受到抑制。
