Raziuddin S, Kibler R F, Morrison D C
J Immunol. 1981 Jul;127(1):13-6.
The immunization of Lewis rats with bacterial lipopolysaccharides (LPS) precomplexed to guinea pig myelin basic protein (BP) in complete Freund's adjuvant inhibits the development of experimental allergic encephalomyelitis (EAE) in these animals. These protected animals fail to manifest significant in vivo delayed-type hypersensitivity skin tests and in vitro lymphocyte proliferative responses to BP. Our results indicated that LPS induces a nonspecific reduction in immune reactivity of BP in Lewis rats.
将细菌脂多糖（LPS）与豚鼠髓鞘碱性蛋白（BP）预先复合后，在完全弗氏佐剂中对Lewis大鼠进行免疫接种，可抑制这些动物实验性变态反应性脑脊髓炎（EAE）的发展。这些受到保护的动物在体内迟发型超敏皮肤试验以及体外淋巴细胞对BP的增殖反应中均未表现出明显反应。我们的结果表明，LPS可导致Lewis大鼠对BP的免疫反应性出现非特异性降低。
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