Department of Medical Laser, Graduate School, College of Medicine, Dankook University, Cheonan 31116, Republic of Korea.
Medical Laser Research Center, College of Medicine, Dankook University, Cheonan 31116, Republic of Korea.
Int J Mol Sci. 2022 Dec 17;23(24):16099. doi: 10.3390/ijms232416099.
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social communication and interaction disorders, as well as repetitive and restrictive behaviors. To date, no effective treatment strategies have been identified. However, photobiomodulation (PBM) is emerging as a promising treatment for neurological and neuropsychiatric disorders. We used mice exposed to valproic acid (VPA) as a model of ASD and found that pathological behavioral and histological changes that may have been induced by VPA were attenuated by PBM treatment. Pregnant mice that had been exposed to VPA were treated with PBM three times. Thereafter, we evaluated the offspring for developmental disorders, motor function, hyperactivity, repetitive behaviors, and cognitive impairment. PBM attenuated many of the pathological behaviors observed in the VPA-induced ASD mouse model. In addition, pathophysiological analyses confirmed that the increase in activated microglia and astrocytes observed in the VPA-induced ASD mouse model was attenuated by PBM treatment. This suggests that PBM can counteract the behavioral changes caused by neuroinflammation in ASD. Therefore, our data show that PBM has therapeutic potential and may reduce the prevalence of neurodevelopmental disorders such as ASD.
自闭症谱系障碍（ASD）是一种神经发育障碍，其特征是社交沟通和互动障碍，以及重复和受限的行为。迄今为止，尚未确定有效的治疗策略。然而，光生物调节（PBM）作为治疗神经和神经精神疾病的方法正在兴起。我们使用暴露于丙戊酸（VPA）的小鼠作为 ASD 的模型，发现 VPA 可能诱导的病理性行为和组织学变化通过 PBM 治疗得到减轻。对暴露于 VPA 的孕鼠进行了三次 PBM 治疗。此后，我们评估了后代的发育障碍、运动功能、多动、重复行为和认知障碍。PBM 减轻了 VPA 诱导的 ASD 小鼠模型中观察到的许多病理性行为。此外，病理生理学分析证实，PBM 治疗减轻了 VPA 诱导的 ASD 小鼠模型中观察到的活化小胶质细胞和星形胶质细胞的增加。这表明 PBM 可以对抗 ASD 中神经炎症引起的行为变化。因此，我们的数据表明 PBM 具有治疗潜力，可能降低神经发育障碍（如 ASD）的患病率。
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