Yan Bingzi, Zhou Jie, Yan Fengshuo, Gao Mingyang, Tang Jiaji, Huang Lin, Luo Yan
Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, China.
The Second Research Institute of Civil Aviation Administration of China, Chengdu, China.
J Cereb Blood Flow Metab. 2025 May;45(5):800-830. doi: 10.1177/0271678X241311695. Epub 2025 Jan 7.
Photobiomodulation (PBM) therapy stands as an innovative neurostimulation modality that has demonstrated both efficacy and safety in improving brain function. This therapy exerts multifaceted influences on neurons, blood vessels, and their intricate interplay known as neurovascular coupling (NVC). Growing evidence indicates that NVC may present a promising target for PBM intervention. However, the detailed mechanisms underlying its therapeutic benefits remain to be fully understood. This review aims to elucidate the potential metabolic pathways and signaling cascades involved in the modulatory effects of PBM, while also exploring the extensive repertoire of PBM applications in neurologic and psychiatric conditions. The prospects of PBM within the realm of NVC investigation are intensively considered, providing deeper insights into the powerful capabilities of PBM therapy and its potential to revolutionize neurostimulation treatments.
光生物调节（PBM）疗法是一种创新的神经刺激方式，已在改善脑功能方面展现出有效性和安全性。该疗法对神经元、血管及其复杂的相互作用（即神经血管耦合，NVC）具有多方面影响。越来越多的证据表明，NVC可能是PBM干预的一个有前景的靶点。然而，其治疗益处背后的详细机制仍有待充分了解。本综述旨在阐明PBM调节作用所涉及的潜在代谢途径和信号级联反应，同时探讨PBM在神经和精神疾病中的广泛应用。深入考虑了PBM在NVC研究领域的前景，以便更深入地了解PBM疗法的强大功能及其革新神经刺激治疗的潜力。
