轴性脊柱关节炎：重塑未来——源自“2022年GISEA国际研讨会”
Axial Spondyloarthritis: Reshape the Future-From the "2022 GISEA International Symposium".
作者信息
Salaffi Fausto, Siragusano Cesare, Alciati Alessandra, Cassone Giulia, D'Angelo Salvatore, Guiducci Serena, Favalli Ennio Giulio, Conti Fabrizio, Gremese Elisa, Iannone Florenzo, Caporali Roberto, Sebastiani Marco, Ferraccioli Gian Franco, Lapadula Giovanni, Atzeni Fabiola
机构信息
Rheumatology Clinic, Ospedale Carlo Urbani, Università Politecnica delle Marche, 60035 Jesi, Italy.
Rheumatology Unit, Department of Experimental and Internal Medicine, University of Messina, 98125 Messina, Italy.
出版信息
J Clin Med. 2022 Dec 19;11(24):7537. doi: 10.3390/jcm11247537.
The term "axial spondyloarthritis" (axSpA) refers to a group of chronic rheumatic diseases that predominantly involve the axial skeleton and consist of ankylosing spondylitis, reactive arthritis, arthritis/spondylitis associated with psoriasis (PsA) and arthritis/spondylitis associated with inflammatory bowel diseases (IBD). Moreover, pain is an important and common symptom of axSpA. It may progress to chronic pain, a more complicated bio-psychosocial phenomena, leading to a significant worsening of quality of life. The development of the axSpA inflammatory process is grounded in the complex interaction between genetic (such as HLA B27), epigenetic, and environmental factors associated with a dysregulated immune response. Considering the pivotal contribution of IL-23 and IL-17 in axSpA inflammation, the inhibition of these cytokines has been evaluated as a potential therapeutic strategy. With this context, here we discuss the main pathogenetic mechanisms, therapeutic approaches and the role of pain in axSpA from the 2022 International GISEA/OEG Symposium.
术语“轴性脊柱关节炎”（axSpA）指的是一组主要累及中轴骨骼的慢性风湿性疾病，包括强直性脊柱炎、反应性关节炎、与银屑病相关的关节炎/脊柱炎（PsA）以及与炎症性肠病（IBD）相关的关节炎/脊柱炎。此外，疼痛是axSpA的一种重要且常见的症状。它可能会发展为慢性疼痛，这是一种更为复杂的生物心理社会现象，会导致生活质量显著下降。axSpA炎症过程的发展基于遗传因素（如HLA B27）、表观遗传因素以及与免疫反应失调相关的环境因素之间的复杂相互作用。鉴于IL-23和IL-17在axSpA炎症中的关键作用，抑制这些细胞因子已被评估为一种潜在的治疗策略。在此背景下，我们将从2022年国际GISEA/OEG研讨会上讨论axSpA的主要发病机制、治疗方法以及疼痛所起的作用。
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