Ricci Vincenzo, Fabozzi Teresa, Bareschino Maria Anna, Barletta Emiddio, Germano Domenico, Paciolla Immacolata, Tinessa Vincenza, Grimaldi Antonio Maria
Medical Oncology Unit, AORN "San Pio", 82100 Benevento, Italy.
Medical Oncology Unit, Ospedale del Mare, 80147 Naples, Italy.
J Pers Med. 2022 Dec 16;12(12):2076. doi: 10.3390/jpm12122076.
Pancreatic cancer is the fourth-leading cause of cancer-related deaths worldwide. The outcomes in patients with pancreatic cancer remain unsatisfactory. In the current review, we summarize the genetic and epigenetic architecture of metastatic pancreatic cancer beyond the BRCA mutations, focusing on the genetic alterations and the molecular pathology in pancreatic cancer. This review focuses on the molecular targets for the treatment of pancreatic cancer, with a correlation to future treatments. The potential approach addressed in this review may lead to the identification of a subset of patients with specific biological behaviors and treatment responses.
胰腺癌是全球癌症相关死亡的第四大原因。胰腺癌患者的治疗结果仍不尽人意。在本综述中，我们总结了除BRCA突变外转移性胰腺癌的遗传和表观遗传结构，重点关注胰腺癌的基因改变和分子病理学。本综述聚焦于胰腺癌治疗的分子靶点及其与未来治疗的相关性。本综述中探讨的潜在方法可能会导致识别出具有特定生物学行为和治疗反应的患者亚群。
