Diode Laser and Polyimide Tape Enables Cheap and Fast Fabrication of Flexible Microfluidic Sensing Devices.

Wearable devices are a new class of healthcare monitoring devices designed for use in close contact with the patient's body. Such devices must be flexible to follow the contours of human anatomy. With numerous potential applications, a wide variety of flexible wearable devices have been created, taking various forms and functions. Therefore, different fabrication techniques and materials are employed, resulting in fragmentation of the list of equipment and materials needed to make different devices. This study attempted to simplify and streamline the fabrication process of all key components, including microfluidic chip and flexible electrode units. A combination of diode laser CNC machine and polyimide tape is used to fabricate flexible microfluidic chip and laser-induced graphene (LIG) electrodes, to create flexible microfluidic sensing devices. Laser ablation on polyimide tape can directly create microfluidic features on either PDMS substrates or LIG electrodes. The two components can be assembled to form a flexible microfluidic sensing device that can perform basic electrochemical analysis and conform to curved surfaces while undergoing microfluidic flow. This study has shown that simple, commonly available equipment and materials can be used to fabricate flexible microfluidic sensing devices quickly and easily, which is highly suitable for rapid prototyping of wearable devices.