Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, Pasadena, CA, USA.
National Key Lab of Micro/Nano Fabrication Technology, Peking University, Beijing, China.
Nat Biotechnol. 2020 Feb;38(2):217-224. doi: 10.1038/s41587-019-0321-x. Epub 2019 Nov 25.
Wearable sweat sensors have the potential to provide continuous measurements of useful biomarkers. However, current sensors cannot accurately detect low analyte concentrations, lack multimodal sensing or are difficult to fabricate at large scale. We report an entirely laser-engraved sensor for simultaneous sweat sampling, chemical sensing and vital-sign monitoring. We demonstrate continuous detection of temperature, respiration rate and low concentrations of uric acid and tyrosine, analytes associated with diseases such as gout and metabolic disorders. We test the performance of the device in both physically trained and untrained subjects under exercise and after a protein-rich diet. We also evaluate its utility for gout monitoring in patients and healthy controls through a purine-rich meal challenge. Levels of uric acid in sweat were higher in patients with gout than in healthy individuals, and a similar trend was observed in serum.
可穿戴汗液传感器具有提供有用生物标志物连续测量的潜力。然而，目前的传感器无法准确检测低浓度分析物，缺乏多模态传感或难以大规模制造。我们报告了一种完全由激光雕刻的传感器，用于汗液采样、化学传感和生命体征监测的同时进行。我们展示了对温度、呼吸率以及与疾病（如痛风和代谢紊乱）相关的低浓度尿酸和酪氨酸的连续检测。我们在运动和高蛋白饮食后，在经过体能训练和未经训练的受试者中测试了该设备的性能。我们还通过富含嘌呤的膳食挑战评估了其在痛风患者和健康对照者中的监测效用。与健康个体相比，痛风患者汗液中的尿酸水平更高，在血清中也观察到类似的趋势。
