Orimo S, Araki M, Ishii H, Ikeda M, Kurosawa T, Arai M, Hiyamuta E
Department of Internal Medicine, Kanto Teishin Hospital, Tokyo, Japan.
J Neurol. 1987 Aug;234(6):424-6. doi: 10.1007/BF00314090.
A 23-year-old man with "myopathy with tubular aggregates" had suffered from exercise-induced muscle cramps for 1 year. His general and neurological findings were normal. Laboratory investigations were within normal limits except for a slightly elevated serum creatine kinase level. Muscle biopsy showed some small angular fibres and scattered type 2B fibres with prominent tubular aggregates originating from the sarcoplasmic reticulum. Since the muscle fibres contracted at a lower concentration of caffeine, increased muscle fibre sensitivity to caffeine is probably related to muscle cramps in this disorder. Tubular aggregates are then secondarily formed in the muscle fibres.
一名患有“伴有管状聚集物的肌病”的23岁男性，运动诱发的肌肉痉挛已持续1年。他的全身及神经系统检查结果均正常。实验室检查除血清肌酸激酶水平略有升高外，其余均在正常范围内。肌肉活检显示一些小的角形纤维和散在的2B型纤维，伴有源自肌浆网的明显管状聚集物。由于肌纤维在较低咖啡因浓度下收缩，肌纤维对咖啡因敏感性增加可能与该疾病的肌肉痉挛有关。然后在肌纤维中继发形成管状聚集物。
