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“肝脏关爱加强版”:提升对高危个体丙型肝炎病毒的初级保健识别与治疗水平。

HepCare Plus: Enhancing Primary Care Identification and Treatment of Hepatitis C Virus in High-Risk Individuals.

作者信息

O'Gorman Tessa, Lambert John S, McHugh Tina, Cullen Walter, Avramovic Gordana, Federico Raffaele, West Bernard, O'Kelly Brendan, Vidal Louise, Farrell Jeremy, Broughan John, O'Connor Eileen, Woo James

机构信息

Mater Misericordiae University Hospital, 7 Dublin, Ireland.

School of Medicine, University College Dublin, 4 Dublin, Ireland.

出版信息

Pathogens. 2022 Nov 27;11(12):1428. doi: 10.3390/pathogens11121428.

DOI:10.3390/pathogens11121428
PMID:36558762
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9781392/
Abstract

Hepatitis C Virus (HCV) disproportionately affects people who inject drugs, migrants, prisoners and the homeless. An integrated, peer-led model of care involving primary and secondary care is required to enhance the identification and treatment of HCV in these marginalised groups. HepCare Plus builds on the network and achievements of HepCare Europe (a co-funded Third Health Programme of the European Union/Health Service Executive project). It further identifies those not accessing care and facilitates prompt assessment and treatment of those diagnosed with HCV, with the aid of a peer support worker (PSW) and a community HCV nurse specialist. Of 109 individuals identified and assessed for HCV treatment, 100 commenced HCV treatment. Despite interruptions to treatment (COVID-19 pandemic and national health service cyberattack) there was a high-level of treatment completion with PSW engagement (98%, n = 98). Eighty (73%) individuals were previously aware of a positive HCV status, highlighting the ongoing need to address barriers preventing marginalised groups from engaging with care. HepCare Plus reiterates the defining role of peer-led community interventions in HCV treatment engagement and the need for continuous open-ended HCV care. It provides a sustainable framework to meaningfully combat HCV and achieve the United Nations Sustainable Development Goal of HCV elimination by 2030.

摘要

丙型肝炎病毒(HCV)对注射吸毒者、移民、囚犯和无家可归者的影响尤为严重。需要一种由同伴主导的综合护理模式,涵盖初级和二级护理,以加强对这些边缘化群体中HCV的识别和治疗。HepCare Plus建立在HepCare Europe(欧盟/卫生服务执行项目共同资助的第三个卫生计划)的网络和成就基础之上。它进一步识别那些未接受护理的人群,并在同伴支持工作者(PSW)和社区HCV护士专家的帮助下,为那些被诊断为HCV的患者提供及时的评估和治疗。在109名被识别并评估接受HCV治疗的个体中,有100人开始了HCV治疗。尽管治疗受到干扰(新冠疫情和国家医疗服务网络攻击),但在PSW的参与下,治疗完成率很高(98%,n = 98)。80名(73%)个体此前已知HCV检测呈阳性,这凸显了持续解决阻碍边缘化群体接受护理的障碍的必要性。HepCare Plus重申了同伴主导的社区干预在HCV治疗参与中的决定性作用,以及持续提供开放式HCV护理的必要性。它提供了一个可持续的框架,以切实抗击HCV,并实现联合国到2030年消除HCV的可持续发展目标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c49f/9781392/f82b6d7145b2/pathogens-11-01428-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c49f/9781392/11fca344aae3/pathogens-11-01428-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c49f/9781392/f82b6d7145b2/pathogens-11-01428-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c49f/9781392/11fca344aae3/pathogens-11-01428-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c49f/9781392/f82b6d7145b2/pathogens-11-01428-g002.jpg

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本文引用的文献

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Integrating Hepatitis C Care for Opioid Substitution Treatment Patients Attending General Practice: Feasibility, Clinical, and Cost-Effectiveness Analysis.为接受阿片类药物替代治疗的患者在全科医疗中整合丙型肝炎护理:可行性、临床及成本效益分析
Interact J Med Res. 2022 Aug 23;11(2):e35300. doi: 10.2196/35300.
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Barriers and facilitators to hepatitis C screening and treatment for people with lived experience of homelessness: A mixed-methods systematic review.具有无家可归经历人群的丙型肝炎筛查和治疗的障碍和促进因素:混合方法系统评价。
Health Expect. 2022 Feb;25(1):48-60. doi: 10.1111/hex.13400. Epub 2021 Dec 3.
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Exploring and understanding HCV patient journeys- HEPCARE Europe project.
探索和了解丙型肝炎患者的就医历程 - HEPCARE Europe 项目。
BMC Infect Dis. 2021 Mar 5;21(1):239. doi: 10.1186/s12879-021-05928-9.
4
Preliminary indications of the burden of COVID-19 among people who inject drugs in England and Northern Ireland and the impact on access to health and harm reduction services.英格兰和北爱尔兰注射吸毒人群中 COVID-19 的负担及其对获得卫生和减少伤害服务的影响的初步迹象。
Public Health. 2021 Mar;192:8-11. doi: 10.1016/j.puhe.2021.01.004. Epub 2021 Jan 15.
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COVID-19 epidemic in the US-A gateway to screen for tuberculosis, HIV, viral hepatitides, Chagas disease, and other neglected tropical diseases among Hispanics.美国的新冠疫情——筛查西班牙裔人群中结核病、艾滋病毒、病毒性肝炎、恰加斯病及其他被忽视热带病的一个窗口。
PLoS Negl Trop Dis. 2020 Dec 18;14(12):e0008953. doi: 10.1371/journal.pntd.0008953. eCollection 2020 Dec.
6
HEPCARE EUROPE- A case study of a service innovation project aiming at improving the elimination of HCV in vulnerable populations in four European cities.HEPCARE EUROPE- 一个旨在改善四个欧洲城市弱势群体中 HCV 消除的服务创新项目的案例研究。
Int J Infect Dis. 2020 Dec;101:374-379. doi: 10.1016/j.ijid.2020.09.1445. Epub 2020 Sep 28.
7
HepCare Ireland-a service innovation project.爱尔兰肝脏护理服务创新项目。
Ir J Med Sci. 2021 May;190(2):587-595. doi: 10.1007/s11845-020-02324-1. Epub 2020 Aug 6.
8
The cost-effectiveness of an HCV outreach intervention for at-risk populations in London, UK.英国伦敦针对高危人群的 HCV 外展干预措施的成本效益。
J Antimicrob Chemother. 2019 Nov 1;74(Suppl 5):v5-v16. doi: 10.1093/jac/dkz451.
9
From peer-based to peer-led: redefining the role of peers across the hepatitis C care pathway: HepCare Europe.从同伴支持到同伴主导:重新定义丙型肝炎护理途径中同伴的角色:HepCare Europe。
J Antimicrob Chemother. 2019 Nov 1;74(Suppl 5):v17-v23. doi: 10.1093/jac/dkz452.
10
Hepcare Europe - bridging the gap in the treatment of hepatitis C: study protocol.《Hepcare Europe - 填补丙型肝炎治疗空白:研究方案》。
Expert Rev Gastroenterol Hepatol. 2018 Mar;12(3):303-314. doi: 10.1080/17474124.2018.1424541. Epub 2018 Jan 16.