Pardeshi Sagar R, Kole Eknath B, Kapare Harshad S, Chandankar Sachin M, Shinde Prashant J, Boisa Ganesh S, Salgaonkar Sanjana S, Giram Prabhanjan S, More Mahesh P, Kolimi Praveen, Nyavanandi Dinesh, Dyawanapelly Sathish, Junnuthula Vijayabhaskarreddy
Department of Pharmaceutics, St. John Institute of Pharmacy and Research, Palghar 401404, India.
University Institute of Chemical Technology, KBC North Maharashtra University, Jalgaon 425001, India.
Pharmaceutics. 2022 Nov 28;14(12):2632. doi: 10.3390/pharmaceutics14122632.
The surface drying process is an important technology in the pharmaceutical, biomedical, and food industries. The final stage of formulation development (i.e., the drying process) faces several challenges, and overall mastering depends on the end step. The advent of new emerging technologies paved the way for commercialization. Thin film freezing (TFF) is a new emerging freeze-drying technique available for various treatment modalities in drug delivery. TFF has now been used for the commercialization of pharmaceuticals, food, and biopharmaceutical products. The present review highlights the fundamentals of TFF along with modulated techniques used for drying pharmaceuticals and biopharmaceuticals. Furthermore, we have covered various therapeutic applications of TFF technology in the development of nanoformulations, dry powder for inhalations and vaccines. TFF holds promise in delivering therapeutics for lung diseases such as fungal infection, bacterial infection, lung dysfunction, and pneumonia.
表面干燥工艺是制药、生物医学和食品工业中的一项重要技术。制剂研发的最后阶段（即干燥过程）面临着若干挑战，而整体掌握情况取决于最后一步。新兴技术的出现为商业化铺平了道路。薄膜冷冻（TFF）是一种新兴的冷冻干燥技术，可用于药物递送中的各种治疗方式。TFF现已用于药品、食品和生物制药产品的商业化。本综述重点介绍了TFF的基本原理以及用于干燥药品和生物制品的调制技术。此外，我们还涵盖了TFF技术在纳米制剂、吸入用干粉和疫苗开发中的各种治疗应用。TFF有望为肺部疾病（如真菌感染、细菌感染、肺功能障碍和肺炎）提供治疗药物。
