Zhao Yiting, Yang Weili, Zheng Kaifeng, Chen Jun, Jin Xiaofeng
Department of Chemoradiotherapy, the Affiliated People's Hospital of Ningbo University, Ningbo 315040, China; Department of Gynecology, The Affiliated People's Hospital of Ningbo University, Ningbo 315040, China; Department of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
Department of Chemoradiotherapy, the Affiliated People's Hospital of Ningbo University, Ningbo 315040, China; Department of Gynecology, The Affiliated People's Hospital of Ningbo University, Ningbo 315040, China.
Gene. 2023 Mar 10;856:147129. doi: 10.1016/j.gene.2022.147129. Epub 2022 Dec 20.
Endometrial cancer (EC) is the third leading gynecological malignancy, and its treatment remains challenging. B cell-specific Moloney murine leukemia virus integration site-1 (BMI1) is one of the core members of the polycomb group (PcG) family, which plays a promoting role in the occurrence and development of various tumors. Notably, BMI1 has been found to be frequently upregulated in endometrial cancer (EC) and promote the occurrence of EC through promoting epithelial-mesenchymal transition (EMT) and AKT/PI3K pathways. This review summarizes the structure and upstream regulatory mechanisms of BMI1 and its role in EC. In addition, we focused on the role of BMI1 in chemoradiotherapy resistance and summarized the current drugs that target BMI1.
子宫内膜癌（EC）是第三大常见的妇科恶性肿瘤，其治疗仍然具有挑战性。B细胞特异性莫洛尼氏鼠白血病病毒整合位点1（BMI1）是多梳蛋白家族（PcG）的核心成员之一，在各种肿瘤的发生和发展中起促进作用。值得注意的是，已发现BMI1在子宫内膜癌（EC）中经常上调，并通过促进上皮-间质转化（EMT）和AKT/PI3K途径促进EC的发生。本综述总结了BMI1的结构和上游调控机制及其在EC中的作用。此外，我们重点关注了BMI1在放化疗耐药中的作用，并总结了目前靶向BMI1的药物。
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