Xia Jiajun, Teng Dengke, Sui Guoqing, Luo Qiang, Lin Yuanqiang, Wang Hui
Department of Ultrasound, China-Japan Union Hospital of Jilin University (all authors), Changchun, Jilin, China.
Department of Ultrasound, China-Japan Union Hospital of Jilin University (all authors), Changchun, Jilin, China..
J Minim Invasive Gynecol. 2023 Apr;30(4):290-299. doi: 10.1016/j.jmig.2022.12.013. Epub 2022 Dec 20.
To evaluate the effectiveness and safety of ultrasound-guided percutaneous microwave ablation (MWA) for a single uterine fibroid greater than 300 cm.
Retrospective observational study.
China-Japan Union Hospital of Jilin University, China.
Thirty-seven patients each with a single fibroid greater than 300 cm diagnosed by ultrasound and core needle biopsy.
Ultrasound-guided percutaneous MWA.
All patients were followed up for 12 months postoperatively to assess the postoperative lesion volume reduction rate, degree of symptomatic relief, improvements in quality of life, and occurrence of adverse events. All 37 patients met the criteria for complete ablation, and the lesion volume significantly decreased from 334.28 cm (95% confidence interval [CI] 326.75-366.73) preoperatively to 52.01 cm (95% CI, 46.95-74.69) at the 12-month follow-up (difference: 280.15 cm; 95% CI, 267.92-294.65; p <.001). The lesion volume reduction rates at 1, 3, 6, and 12 months postoperatively were 27.30% (95% CI, 24.12-31.45), 52.90% (95% CI, 47.95-55.80), 67.90% (95% CI, 63.03-70.77), and 84.00% (95% CI, 80.22-85.94), respectively. The differences in the preoperative and postoperative Uterine Fibroid Symptom and Health-Related Quality of Life Questionnaire scores were significant (p <.01). The hemoglobin levels of the anemic patients were significantly elevated after the procedure (p <.001). Of the 37 patients in this study, 29 patients (78.38%) had a highly significant treatment effect, and 8 patients (21.62%) had a significant treatment effect. Seventeen patients (45.95%) had Society of Interventional Radiology grade A to B adverse effects that required no clinical intervention or only simple clinical intervention.
Ultrasound-guided percutaneous MWA has good clinical efficacy and high safety in the treatment of a single uterine fibroid greater than 300 cm.
评估超声引导下经皮微波消融术（MWA）治疗单个直径大于3cm子宫肌瘤的有效性和安全性。
回顾性观察研究。
中国吉林大学中日联谊医院。
37例经超声及粗针活检确诊为单个直径大于3cm子宫肌瘤的患者。
超声引导下经皮MWA。
所有患者术后随访12个月，评估术后病灶体积缩小率、症状缓解程度、生活质量改善情况及不良事件发生情况。37例患者均达到完全消融标准，病灶体积术前为334.28cm（95%置信区间[CI]326.75 - 366.73），12个月随访时降至52.01cm（95%CI，46.95 - 74.69）（差值：280.15cm；95%CI，267.92 - 294.65；p <.001）。术后1、3、6及12个月病灶体积缩小率分别为27.30%（95%CI，24.12 - 31.45）、52.90%（95%CI，47.95 - 55.80）、67.90%（95%CI，63.03 - 70.77）及84.00%（95%CI，80.22 - 85.94）。术前及术后子宫肌瘤症状与健康相关生活质量问卷评分差异有统计学意义（p <.01）。贫血患者术后血红蛋白水平显著升高（p <.001）。本研究37例患者中，29例（78.38%）治疗效果高度显著，8例（21.62%）治疗效果显著。17例患者（45.95%）出现介入放射学会A至B级不良反应，无需临床干预或仅需简单临床干预。
超声引导下经皮MWA治疗单个直径大于3cm子宫肌瘤具有良好的临床疗效和较高的安全性。
