Fowler J E, Clayton M, Mouli K, Reagan G
Division of Urology, University of Illinois College of Medicine, Chicago 60680.
J Urol. 1987 Oct;138(4):735-8. doi: 10.1016/s0022-5347(17)43356-8.
We assessed the impact of twice daily instillations of 10 ml. liquid diphenoxylate hydrochloride and atropine sulfate (Lomotil) on the dynamics and function of continent urinary reservoirs constructed from intact cecum and ascending colon. Six patients were treated for 1 to 3 weeks at 3 to 8 months postoperatively. The treatments reduced the frequency of spontaneous reservoir contractions, as well as the basal and contraction pressures of the reservoirs. The reservoir capacities were increased modestly. These alterations in reservoir dynamics were accompanied by a decrease in the cramping characteristically associated with reservoir distension and increased intervals between reservoir catheterization. Two patients who had incontinence after initially successful operations regained continence during treatment. No systemic side effects were observed, although dilution of the drug may be required to prevent reservoir irritability. Diphenoxylate hydrochloride and atropine sulfate instillations may prevent acute and possibly long-term pressure-related complications of continent urinary reservoirs constructed from intact cecum and ascending colon.
我们评估了每日两次滴注10毫升液体盐酸地芬诺酯和硫酸阿托品（复方苯乙哌啶）对由完整盲肠和升结肠构建的可控性尿流改道贮尿囊的动力学和功能的影响。6例患者在术后3至8个月接受了1至3周的治疗。这些治疗降低了贮尿囊自发收缩的频率，以及贮尿囊的基础压力和收缩压力。贮尿囊容量略有增加。贮尿囊动力学的这些改变伴随着与贮尿囊扩张相关的痉挛性疼痛减少以及贮尿囊插管间隔时间延长。两名最初手术成功后出现尿失禁的患者在治疗期间恢复了控尿能力。尽管可能需要稀释药物以防止贮尿囊激惹，但未观察到全身副作用。滴注盐酸地芬诺酯和硫酸阿托品可能预防由完整盲肠和升结肠构建的可控性尿流改道贮尿囊的急性以及可能的长期压力相关并发症。
