Regranulation of islets of Langerhans and normalization of in vivo insulin secretion in ob/ob mice treated with oxytetracycline.

Oxytetracycline (OTC) treatment was associated with regranulation of the islet cells and increased pancreatic insulin content in the ob/ob mouse. This was accompanied by an improvement of the in vivo insulin secretory response to glucose. Because of the wide-ranging effects of OTC on other membrane-related functions, it is postulated that this compound may exert ist effect by altering the composition of cellular membranes.