Feldman Matthew, Marmol Sarah, Margolesky Jason
Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
Ther Clin Risk Manag. 2022 Dec 20;18:1129-1142. doi: 10.2147/TCRM.S360268. eCollection 2022.
Parkinsonism refers to the clinical combination of bradykinesia, rigidity, tremor, and postural instability. Parkinsonism is often neurodegenerative, but it can be secondary or iatrogenic, as in drug-induced parkinsonism (DIP), which is the topic of this review. We review the pathophysiology of DIP, differentiate DIP and idiopathic Parkinson's disease (PD), list culprit medications in the development of DIP, discuss the diagnosis of DIP as well as the motor and nonmotor signs and symptoms that can help with differentiation of DIP and PD, and detail the management of DIP.
帕金森综合征是指运动迟缓、肌强直、震颤和姿势不稳的临床组合。帕金森综合征通常是神经退行性疾病，但也可能是继发性或医源性的，如药物性帕金森综合征（DIP），这是本综述的主题。我们回顾了DIP的病理生理学，区分了DIP和特发性帕金森病（PD），列出了导致DIP的罪魁祸首药物，讨论了DIP的诊断以及有助于区分DIP和PD的运动和非运动体征及症状，并详细介绍了DIP的管理。
