Polonskaia N Iu, Solov'eva L P
Med Radiol (Mosk). 1987 Oct;32(10):48-51.
Altogether 70 patients with histologically verified laryngeal cancer were studied. An analysis of the data obtained showed that tumor proliferative activity expressed by a labeling index (LI) correlated, to a certain extent, with various structural and functional properties of a tumor, e. g. LI showed correlation with a degree of differentiation of squamous cell carcinoma: in a nonkeratinizing type the mean LI was 8.2, in a keratinizing type 5.5. A noticeable immune response to a tumor was observed in most of the patients. However a stable tendency (p = 0.95) to a decrease in LI in marked lymphoid infiltration was revealed in nonkeratinizing squamous cell carcinoma only. There was no correlation between LI and a degree of vascularization. The preponderance of weak vascularization was noted in keratinizing squamous cell carcinoma. A decrease in LI in weak vascularization was also observed in this cancer type taking into account a degree of lymphoid infiltration. In clinical practice while designing a therapy one should bear in mind a variety of clinical, structural and biological features of a tumor.
共对70例经组织学证实的喉癌患者进行了研究。对所获数据的分析表明，由标记指数（LI）所表达的肿瘤增殖活性在一定程度上与肿瘤的各种结构和功能特性相关，例如LI与鳞状细胞癌的分化程度相关：在非角化型中，平均LI为8.2，在角化型中为5.5。在大多数患者中观察到了对肿瘤的明显免疫反应。然而，仅在非角化鳞状细胞癌中发现，在明显的淋巴细胞浸润时LI有稳定的下降趋势（p = 0.95）。LI与血管化程度之间无相关性。在角化鳞状细胞癌中观察到血管化程度较弱占优势。考虑到淋巴细胞浸润程度，在这种癌症类型中也观察到血管化程度较弱时LI下降。在临床实践中，在设计治疗方案时应考虑肿瘤的各种临床、结构和生物学特征。
