Department of Cardiology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, Delhi, India.
Department of Cardiology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, Delhi, India.
Indian Heart J. 2023 Jan-Feb;75(1):68-72. doi: 10.1016/j.ihj.2022.11.014. Epub 2022 Nov 26.
There is an increasing prevalence of coronary artery disease (CAD) in younger individuals. Lipid biomarkers such as lipoprotein-a (Lp-a), Apo A1, Apo B and Paraoxonase-1 (PON1) serve as important risk predictors for development of CAD. There is little evidence regarding the role of lipid biomarkers and their genetic polymorphisms in young (<50 years) ST-segment elevation myocardial infarction (STEMI) patients.
This study included 110 young (18-50 years) STEMI patients and 110 healthy controls. Serum levels of Apo A1, Apo B, Paraoxonase-1 (PON-1) and Lipoprotein-associated phospholipase A2 (Lp-PLA2) were estimated for both patients as well as controls. Additionally, genetic polymorphisms in the Apo A1 (75G/A) and the PON1 (Q192R) genes were evaluated.
Serum levels of apo B (101.31 ± 27.58 vs 75.31 ± 18.77 mg/dl; p < 0.0001), Lp(a) [87.56 ± 74.28 vs 25.81 ± 24.66 mg/dl, p < 0.0001] and Lp-PLA2 [5.97 ± 1.39 vs 3.49 ± 1.27 ng/mL, p < 0.0001] were significantly higher in patients as compared to controls. Serum levels of Apo A1 [44.76 ± 35.65 vs 95.97 ± 29.89; p < 0.0001] and PON1 [2.63 ± 1.5 vs 3.87 ± 1.47 ng/mL, p < 0.0001] were significantly lower in cases as compared with controls. Additionally, patients with genetic polymorphisms in the Apo A1 (75G/A) and the PON1 (Q192R) gene had an increased risk of STEMI.
Lipid biomarkers such as Apo A1, Apo B and PON1 and their genetic polymorphism are associated with the susceptibility for STEMI in young individuals.
冠心病（CAD）在年轻人中的发病率呈上升趋势。脂蛋白-a（Lp-a）、载脂蛋白 A1（Apo A1）、载脂蛋白 B（Apo B）和对氧磷酶-1（PON1）等脂质生物标志物是 CAD 发展的重要风险预测因子。然而，关于脂质生物标志物及其遗传多态性在年轻（<50 岁）ST 段抬高型心肌梗死（STEMI）患者中的作用的证据较少。
本研究纳入了 110 名年轻（18-50 岁）STEMI 患者和 110 名健康对照者。对患者和对照组均测定血清载脂蛋白 A1（Apo A1）、Apo B、对氧磷酶-1（PON1）和脂蛋白相关磷脂酶 A2（Lp-PLA2）水平。此外，还评估了 Apo A1（75G/A）和 PON1（Q192R）基因的遗传多态性。
与对照组相比，患者的血清载脂蛋白 B（101.31±27.58 与 75.31±18.77mg/dl；p<0.0001）、Lp(a) [87.56±74.28 与 25.81±24.66mg/dl，p<0.0001] 和 Lp-PLA2 [5.97±1.39 与 3.49±1.27ng/ml，p<0.0001] 水平显著升高。与对照组相比，患者的血清载脂蛋白 A1（44.76±35.65 与 95.97±29.89；p<0.0001）和 PON1 [2.63±1.5 与 3.87±1.47ng/ml，p<0.0001] 水平显著降低。此外，Apo A1（75G/A）和 PON1（Q192R）基因存在遗传多态性的患者发生 STEMI 的风险增加。
Apo A1、Apo B 和 PON1 等脂质生物标志物及其遗传多态性与年轻人发生 STEMI 的易感性相关。
