Department of Urology, Faculty of Medicine (for Girls), Al-Azhar University, Cairo.
Department of Internal medicine, Faculty of Medicine (for Girls), Al-Azhar University, Cairo.
Arch Ital Urol Androl. 2022 Dec 27;94(4):443-446. doi: 10.4081/aiua.2022.4.443.
To evaluate the role of urinary Monocyte Chemotactic Protein-1 (MCP1) and urinary epidermal growth factor (EGF) in diagnosing of upper urinary tract obstruction (UUTO).
Over a period of 6 months (January 2022 to June 2022) this prospective case control comparative study was conducted on 120 participants, 60 of them with UUTO and 60 healthy controls. A morning urine sample of all participants was tested for EGF and MCP-1. after taking a detailed history taking and laboratory and radiological evaluation.
Urinary MCP-1(uMCP-1) was significantly (p-value = 0.000) increased in UUTO group showing a mean ± SD of 518.10 ± 51.19 ng/L compared to a mean ± SD of 143.32 ± 58.03 ng/L in the controls, whereas a significantly (p-value = 0.000) decrease of urinary EGF (uEGF) was observed in patients with UUTO compared to control group. A significant difference of uEGF level and uEGF/uMCP1 ratio was observed between mild compared to moderate/severe UUTO.
Utilization of the urinary biomarker MCP1, EGF and uEGF/uMCP1 ratio in patients with UUTO can adequately be used as a simple, efficacious and noninvasive way in diagnosis of UUTO.
评估尿单核细胞趋化蛋白-1（MCP1）和尿表皮生长因子（EGF）在上尿路梗阻（UUTO）诊断中的作用。
本前瞻性病例对照研究于 2022 年 1 月至 6 月期间进行，共纳入 120 名参与者，其中 60 名患有 UUTO，60 名健康对照。所有参与者的晨尿样本均用于检测 EGF 和 MCP-1。在进行详细的病史采集以及实验室和影像学评估后。
UUTO 组尿 MCP-1（uMCP-1）显著升高（p 值=0.000），平均±标准差为 518.10±51.19ng/L，而对照组平均±标准差为 143.32±58.03ng/L，差异有统计学意义。与对照组相比，UUTO 患者的尿 EGF（uEGF）显著降低。与轻度 UUTO 相比，中重度 UUTO 患者的 uEGF 水平和 uEGF/uMCP1 比值差异有统计学意义。
在 UUTO 患者中，尿生物标志物 MCP1、EGF 和 uEGF/uMCP1 比值的检测可作为一种简单、有效、非侵入性的方法，用于 UUTO 的诊断。
