Amiri Mohammad, Gerami Reza, Shekarchi Babak, Azimi Amirreza, Asadi Bahador, Bagheri Hamed
Faculty of Medicine, Aja University of Medical Science, Tehran, Iran.
Department of Radiology, Faculty of Medicine, Aja University of Medical Science, Tehran, Iran.
Eur J Radiol Open. 2022 Dec 15;10:100465. doi: 10.1016/j.ejro.2022.100465. eCollection 2023.
Multiple sclerosis (MS) is recognized as the most prevalent autoimmune abnormality of the CNS. T1WI, T2WI, and FLAIR are limited in the quantification of tissue damage and detection of tissue alterations in white and grey matter in MS. This study aimed to the evaluation of changes in DTI indices in these patients at the thalamus and basal ganglia.
30 relapsing-remitting MS (RRMS) cases and 30 normal individuals were included. Conventional MRI (T2, FLAIR) was acquired to confirm NAGM in MS patients. A T1 MPRAGE protocol was used to normalize DTI images. FSL, SPM, and Explore DTI software were employed to reach Mean Diffusivities (MD), Axial Diffusivities (AD), Fractional anisotropy (FA), and Radial Diffusivity (RD) at the thalamus and the basal ganglia.
The FA and RD of the thalamus were decreased in healthy controls compared to MS cases (0.319 vs. 0.296 and 0.0009 vs. 0.0006, respectively) (P < 0.05). The AD value in the thalamus and the FA value in the caudate nucleus were significantly lower in MS cases than in controls (0.0009 vs. 0.0011 and 0.16 vs. 0.18, respectively) (P < 0.05). MD values in the thalamus or basal ganglia were not significantly different between groups.
DTI measures including FA, RD, and AD have a good diagnostic performance in detecting microstructural changes in the normal-appearing thalamus in cases with RRMS while they had no significant relationship with clinical signs in terms of EDSS.
Not applicable.
多发性硬化症（MS）被认为是中枢神经系统最常见的自身免疫异常疾病。T1加权成像（T1WI）、T2加权成像（T2WI）和液体衰减反转恢复序列（FLAIR）在MS患者白质和灰质的组织损伤定量及组织改变检测方面存在局限性。本研究旨在评估这些患者丘脑和基底节区扩散张量成像（DTI）指标的变化。
纳入30例复发缓解型MS（RRMS）患者和30名正常个体。采集常规MRI（T2、FLAIR）以确认MS患者的正常外观灰质（NAGM）。采用T1磁化准备快速梯度回波序列（T1 MPRAGE）对DTI图像进行标准化。使用FSL、统计参数映射（SPM）和Explore DTI软件获取丘脑和基底节区的平均扩散率（MD）、轴向扩散率（AD）、分数各向异性（FA）和径向扩散率（RD）。
与MS患者相比，健康对照者丘脑的FA和RD降低（分别为0.319对0.296和0.0009对0.0006）（P<0.05）。MS患者丘脑的AD值和尾状核的FA值显著低于对照组（分别为0.0009对0.0011和0.16对0.18）（P<0.05）。丘脑或基底节区的MD值在两组之间无显著差异。
包括FA、RD和AD在内的DTI测量在检测RRMS患者正常外观丘脑中的微观结构变化方面具有良好的诊断性能，而它们与扩展残疾状态量表（EDSS）方面的临床体征无显著关系。
不适用。
