Wu Wen-Yang, Chang Shih-Chun, Hsu Jun-Te, Yeh Ta-Sen, Liu Keng-Hao
Division of General Surgery, Department of Surgery, Linkou Chang-Gung Memorial Hospital, Taoyuan 333, Taiwan.
School of Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
J Pers Med. 2022 Oct 31;12(11):1795. doi: 10.3390/jpm12111795.
(1) Background: Laparoscopic sleeve gastrectomy (LSG) is widely performed in bariatric surgery. However, the prevalence and risk factors of gastroesophageal reflux disease (GERD) symptoms after LSG remain unclear to date. This study aimed to identify risk factors of GERD after LSG. (2) Methods: We conducted a retrospective study at Linkou Chang Gung Memorial Hospital and reviewed 296 patients who underwent LSG from 2016 to 2019. A total of 143 patients who underwent preoperative esophagogastroduodenoscopy and completed the 12-month postoperative follow-up were enrolled. Patients’ demographic data, comorbidities, and postoperative weight loss results were recorded for analysis. The GerdQ questionnaire was used to assess GERD after LSG. (3) Results: There were eight surgical complications (5.6%) among the 143 studied patients (median age, 36 years; 56 (39.2%) men; median body weight 105.5 kg; median body mass index [BMI], 38.5 kg/m2). Twenty-three patients (16.1%) developed de novo GERD symptoms. GERD was significantly associated with older age (p = 0.022) and lower BMI (<35 kg/m2, p = 0.028). In multiple logistic regression analysis, age and BMI were significantly associated with GERD. (4) Conclusions: LSG is a safe and effective weight loss surgery. In our study, it led to 16.1% of de novo GERD symptoms, which were significantly related to older age and lower BMI (<35 kg/m2).
（1）背景：腹腔镜袖状胃切除术（LSG）在减肥手术中被广泛应用。然而，迄今为止，LSG术后胃食管反流病（GERD）症状的发生率及危险因素仍不明确。本研究旨在确定LSG术后GERD的危险因素。（2）方法：我们在林口长庚纪念医院进行了一项回顾性研究，回顾了2016年至2019年期间接受LSG的296例患者。共纳入143例术前接受食管胃十二指肠镜检查并完成术后12个月随访的患者。记录患者的人口统计学数据、合并症及术后体重减轻结果进行分析。采用GerdQ问卷评估LSG术后的GERD情况。（3）结果：在143例研究患者中（中位年龄36岁；56例（39.2%）为男性；中位体重105.5 kg；中位体重指数[BMI]为38.5 kg/m²），发生了8例手术并发症（5.6%）。23例患者（16.1%）出现新发GERD症状。GERD与年龄较大（p = 0.022）及BMI较低（<35 kg/m²，p = 0.028）显著相关。在多因素逻辑回归分析中，年龄和BMI与GERD显著相关。（4）结论：LSG是一种安全有效的减肥手术。在我们的研究中，它导致16.1%的患者出现新发GERD症状，这些症状与年龄较大及BMI较低（<35 kg/m²）显著相关。
