Lammintausta R
Int J Clin Pharmacol Biopharm. 1978 Dec;16(12):581-4.
Ten patients with hypertensive pregnancy were studied in hospital for 3 weeks. Plasma renin activity (PRA), the daily urinary excretion of aldosterone (dU-Aldo) and electrolytes were studied before and during dihydralazine therapy (25 mg 3 times daily). In one week the supine blood pressure decreased (p less than 0.05) without any discernible tachycardia. PRA increased in 3 days of the treatment by 50% (p less than 0.05) and this mean level was maintained. In dU-Aldo no change was found, however, during the study; and the excretions of sodium and potassium remained unchanged as well. In patients without diuretic therapy the basal PRA level before dihydralazine therapy was lower than in normal pregnancy. Also, in patients with preceding diuretic therapy the basal level of PRA was lower than during diuretics in gravidas without hypertension. Judging from the animal experiments, the rise in PRA might be seen as favorable for uteroplacental circulation in pregnancy hypertension.
对10例妊娠高血压患者进行了为期3周的住院研究。在使用双肼屈嗪治疗前及治疗期间（每日3次，每次25mg），对血浆肾素活性（PRA）、醛固酮每日尿排泄量（dU-Aldo）及电解质进行了研究。在1周内，仰卧位血压下降（p<0.05），且无明显心动过速。治疗3天时PRA升高50%（p<0.05），且该平均水平得以维持。然而，在研究期间，dU-Aldo未发现变化；钠和钾的排泄也保持不变。在未接受利尿剂治疗的患者中，双肼屈嗪治疗前的基础PRA水平低于正常妊娠者。此外，在先前接受过利尿剂治疗的患者中，PRA的基础水平低于无高血压孕妇使用利尿剂期间的水平。从动物实验判断，PRA升高可能被视为有利于妊娠高血压患者的子宫胎盘循环。
