Salvetti A, Pedrinelli R, Simonini N
Int J Clin Pharmacol Ther Toxicol. 1982 Nov;20(11):538-42.
The interrelationship between PRA, urinary aldosterone excretion, and blood pressure was studied in 11 patients with essential hypertension while receiving a diuretic (1st week) and subsequently a diuretic + oxprenolol (2nd week). The diuretic reduced blood pressure and body weight but increased PRA and aldosterone. Oxprenolol reduced PRA on the 1st day but to a lesser extent on the 7th day. Blood pressure was decreased 1 day after oxprenolol administration, but to a greater extent on the 7th day. Blood pressure decrements were independent of renin suppression, but directly correlated to aldosterone changes. These data suggest that the hypotensive effect of oxprenolol in patients receiving diuretic treatment is independent of its suppression of renin. Aldosterone suppression may instead contribute to the hypotensive effect of the drug.
在11例原发性高血压患者中，研究了血浆肾素活性（PRA）、尿醛固酮排泄与血压之间的相互关系。这些患者在第1周接受利尿剂治疗，随后在第2周接受利尿剂+氧烯洛尔治疗。利尿剂降低了血压和体重，但增加了PRA和醛固酮。氧烯洛尔在第1天降低了PRA，但在第7天降低程度较小。氧烯洛尔给药1天后血压下降，但在第7天下降幅度更大。血压下降与肾素抑制无关，但与醛固酮变化直接相关。这些数据表明，在接受利尿剂治疗的患者中，氧烯洛尔的降压作用与其对肾素的抑制作用无关。相反，醛固酮抑制可能有助于该药物的降压作用。
