Michel Martin C, Heemann Uwe, de la Rosette Jean J M C H
Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany.
Department of Medicine, University Medical Center, Munich, Germany.
Front Pharmacol. 2022 Dec 13;13:1081074. doi: 10.3389/fphar.2022.1081074. eCollection 2022.
While animal studies have suggested an association between the presence of hypertension and the presence and/or severity of overactive bladder syndrome (OAB) symptoms, little clinical data is available. We have conducted a pre-specified secondary analysis of a non-interventional study involving 4450 OAB patients being treated with solifenacin to explore the existence of an association between OAB and hypertension using three parallel and overlapping definitions of hypertension to enhance robustness of analysis. Regardless of definition, patients with hypertension were older and had greater OAB symptom severity in univariate analyses. In multiple regression models including age as explanatory covariate, most relationships held up but effect sizes of concomitant hypertension on OAB severity were small (odds ratios <1.35 in all cases) and were deemed to be unlikely of clinical relevance. % Changes in symptom severity were somewhat smaller in univariate analysis, but effect sizes were small. We conclude that OAB and arterial hypertension are associated but effect sizes are too small to justify adaptation of clinical practice for OAB patients with concomitant hypertension.
虽然动物研究表明高血压的存在与膀胱过度活动症（OAB）症状的存在和/或严重程度之间存在关联，但临床数据很少。我们对一项涉及4450例接受索利那新治疗的OAB患者的非干预性研究进行了预先设定的二次分析，使用三种平行且重叠的高血压定义来探讨OAB与高血压之间的关联，以增强分析的稳健性。无论采用何种定义，在单变量分析中，高血压患者年龄更大，OAB症状更严重。在将年龄作为解释性协变量的多元回归模型中，大多数关系依然成立，但伴发高血压对OAB严重程度的效应大小较小（所有情况下比值比均<1.35），被认为不太可能具有临床相关性。单变量分析中症状严重程度的百分比变化略小，但效应大小也较小。我们得出结论，OAB与动脉高血压有关联，但效应大小过小，不足以证明需要调整对伴有高血压的OAB患者的临床治疗方案。
